Antenatal and Intrapartum Risk Factors for Seizures in Term Newborns: A Population-Based Study, California 1998-2002
Antenatal and Intrapartum Risk Factors for Seizures in Term Newborns: A Population-Based Study, California 1998-2002
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DOI：
10.1016/j.jpeds.2008.07.008
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发表时间：
2009-01-01
影响因子：
5.1
通讯作者：
Wu, Yvonne W.
中科院分区：
文献类型：
--
作者：
Glass, Hannah C.;Pham, Trinh N.;Wu, Yvonne W.
目的 评估入院期间发生癫痫发作的产前和产时危险因素。研究设计 使用多变量逻辑回归分析，我们使用包含与婴儿和产妇出院摘要相关的出生证明的加州全州规划和发展办公室数据库，评估了 1998 年至 2002 年期间出生的 230 万加州妊娠 36 周以上儿童的队列中母亲特征与入院癫痫发作之间的关联。结果 入院期间癫痫发作的发生率为 0.95/1000 活产儿。在一项调整分析中，40 岁及以上未生育女性的婴儿；患有糖尿病、产时发烧或感染或分娩时间 >= 42 周的患者癫痫发作的风险增加。与白种人母亲的婴儿相比，西班牙裔和亚裔母亲的婴儿的风险较低。结论 一些母亲的产前和产时因素增加了入院期间癫痫发作的风险。识别和避免新生儿癫痫发作的风险可能会降低婴儿神经系统发病率和死亡率。 （儿科杂志 2009；154：24-8）
Objective To assess antenatal and intrapartum risk factors for seizures occurring during the birth admission.Study design Using muiltivariable logistic regression analysis, we evaluated the association between maternal characteristics and birth admission seizures in a cohort of 2.3 million California children born at >= 36 weeks' gestation between 1998 and 2002 using the California Office of Statewide Planning and Development database containing birth certificates linked to infant and maternal hospital discharge abstracts.Results The incidence of seizures during the birth admission was 0.95/1000 live births. In an adjusted analysis, infants of women age 40 years and older who were nulliparous; had diabetes mellitus, intrapartum fever, or infection or delivered at >= 42 weeks had an increased risk of seizures. Infants of Hispanic and Asian mothers had a lower risk compared with infants of Caucasian mothers.Conclusions Several maternal antenatal and intrapartum factors increased the risk of seizures during the birth admission. Identifying and avoiding risks for neonatal seizures may lead to lower infant neurologic morbidity and mortality. (J Pediatr 2009;154:24-8)