Focal magnetic resonance guided focused ultrasound for prostate cancer: Initial North American experience
Focal magnetic resonance guided focused ultrasound for prostate cancer: Initial North American experience
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DOI：
10.5489/cuaj.12218
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发表时间：
2012-12-01
影响因子：
1.9
通讯作者：
Trachtenberg, John
中科院分区：
文献类型：
--
作者：
Lindner, Uri;Ghai, Sangeet;Trachtenberg, John
低风险前列腺癌的治疗是一个常见的临床困境，在标准的治疗性全腺体治疗（及其相关的生活质量降低的副作用）和主动监测（及其低但真实的进展风险）之间。低风险前列腺癌局灶治疗的目标是在癌症控制和维持生活质量之间取得最佳平衡。磁共振引导聚焦超声（MRgFUS）手术是一种将磁共振成像识别靶标、治疗计划和热沉积闭环控制与聚焦超声对肿瘤靶标进行热消融相结合的非侵入性热消融方法。这种新型的经直肠系统允许肿瘤定位、靶向和实时监测肿瘤靶向消融，同时保留邻近的正常组织，从而最大限度地减少标准治疗性手术或放射治疗的副作用。我们报告了北美首个应用局灶性磁共振引导经直肠聚焦超声治疗局限性前列腺癌的临床经验（临床试验网站标识NCT01226576）。
The treatment of low-risk prostate cancer is a common clinical dilemma between standard curative whole gland therapy (and its associated quality of life diminishing side effects) and active surveillance (and its low, but real, risk of progression). The goal of focal therapy in low-risk prostate cancer is to achieve the best balance between cancer control and maintenance of quality of life. Magnetic resonance-guided focused ultrasound (MRgFUS) surgery is a non-invasive thermal ablation method that integrates magnetic resonance imaging for target identification, treatment planning and closed-loop control of thermal deposition and focused ultrasound for thermal ablation of the tumour target. This novel transrectal system allows for tumour localization, targeting and monitoring of tumour target ablation in real time, while simultaneously preserving adjacent normal tissue thereby minimizing the side effects of standard curative surgical or radiation therapy. We report the first North American clinical experience of treatment of localized prostate cancer with focal MR-guided transrectal focused ultrasound (clinicaltrial.gov identifier NCT01226576).