ortho-C_H Acetoxylation of Cubane Enabling Access to Cubane Analogues of Pharmaceutically Relevant Scaffolds
ortho-C_H Acetoxylation of Cubane Enabling Access to Cubane Analogues of Pharmaceutically Relevant Scaffolds
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古巴烷的邻 C_H 乙酰氧基化使得能够获得药物相关支架的古巴烷类似物
DOI：
10.1021/acs.orglett.1c03144
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Yoshiharu Iwabuchi
中科院分区：
文献类型：
--
作者：
Shota Nagasawa;Masaki Hosaka;Yoshiharu Iwabuchi
利用过渡金属催化的C-H活化直接乙酰氧基化方法，开发了一种在立方烷核心中引入氧官能团的新方法。得到的化合物被衍生为与药物相关的结构基序的立方烷类似物，即乙酰水杨酸和香豆素基序，它们可能作为这些支架的生物等位体。
A novel method of introducing an oxygen functionality into a cubane core was developed using a transition-metal-catalyzed directed acetoxylation methodology via C–H activation. The obtained compounds were derivatized into cubane analogues of pharmaceutically relevant structural motifs, namely, acetylsalicylic acid and coumarin motifs, which could potentially act as bioisosteres of these scaffolds.