Basilar Artery Atherosclerosis and Hypertensive Small Vessel Disease in Isolated Pontine Infarctions: A Study Based on High-Resolution MRI
Basilar Artery Atherosclerosis and Hypertensive Small Vessel Disease in Isolated Pontine Infarctions: A Study Based on High-Resolution MRI
复制标题
孤立性脑桥梗塞中的基底动脉粥样硬化和高血压小血管疾病：基于高分辨率 MRI 的研究
DOI：
10.1159/000346577
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发表时间：
2013-01-01
影响因子：
2.4
通讯作者：
Huang, Jing
中科院分区：
文献类型：
--
作者：
Feng, Chao;Xu, Yu;Huang, Jing
背景资料：孤立性脑桥梗死分为旁正中脑桥梗死（PPI）和腔隙性脑桥梗死（LPI），通常分别归因于基底动脉（BA）动脉粥样硬化和小血管疾病（SVD）。近年来，研究者在LPI中发现了BA动脉粥样硬化斑块，使LPI的发病机制变得混乱。研究方法：我们用高分辨率MRI和SVD负荷评估了BA斑块的存在和位置，以及高血压、脑白质疏松和无症状性脑梗死的存在。结果：PPI和LPI之间BA斑块和SVD的发生率相似，大多数斑块与相应的梗死相关。部分PPI无斑块;部分LPI无明显SVD。结论：SVD和BA斑块伴或不伴管腔狭窄均是PPI和LPI的可能原因。版权所有（C）2013 S. Karger AG，巴塞尔
Background: Isolated pontine infarctions are classified as paramedian pontine infarction (PPI) and lacunar pontine infarction (LPI), usually attributed to basilar artery (BA) atherosclerosis and small vessel disease (SVD), respectively. Recently, researchers found BA atherosclerotic plaques in LPI and made the pathogenesis of LPI confusing. Methods: We evaluated the presence and location of BA plaques with high-resolution MRI and SVD burden with presence of hypertension, leukoaraiosis and silent brain infarction. Results: The prevalence of BA plaques and SVD was similar between PPI and LPI, with most plaques relevant to corresponding infarctions. Some PPI had no plaques; some LPI had no obvious SVD. Conclusion: SVD and BA plaques with or without lumen stenosis were both possible causes of PPI and LPI. Copyright (C) 2013 S. Karger AG, Basel