UNRESECTABLE HEPATOCELLULAR-CARCINOMA - ANALYSIS OF PROGNOSTIC FACTORS IN TRANSCATHETER MANAGEMENT
UNRESECTABLE HEPATOCELLULAR-CARCINOMA - ANALYSIS OF PROGNOSTIC FACTORS IN TRANSCATHETER MANAGEMENT
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DOI：
10.1148/radiology.195.3.7754005
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发表时间：
1995-06-01
期刊：
影响因子：
19.7
通讯作者：
MIYAO, M
中科院分区：
文献类型：
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作者：
HATANAKA, Y;YAMASHITA, Y;MIYAO, M
目的：评价肝细胞癌介入治疗对生存率的影响。材料与方法：对不能切除的肝细胞癌患者进行经导管动脉栓塞术(TAE)的前瞻性试验。322例患者(男2 65例，女57例；年龄30~83岁)：60例采用含抗癌剂的明胶海绵(GS)行TAE(方案1)，78例采用含GS加碘油加抗癌剂的TAE(方案2)，15 9例行TAE加碘油加抗癌剂(方案3)。结果：随机组(n=272)1年生存率分别为80.4%、86.3%和65.9%。影响预后的因素分析显示，肝外转移、腹水、肿瘤扩散、黄疸是影响预后的重要因素。结论：伴有GS的TAE优于无GS的TAE。患者特征是影响生存的重要因素。
PURPOSE: To evaluate the effect of transcatheter management of hepatocellular carcinoma (HCC) on survival.MATERIALS AND METHODS: A prospective trial of transcatheter arterial embolization (TAE) was performed in patients with unresectable HCC. Three hundred twenty-two patients (265 men, 57 women; age range, 30-83 years) underwent TAE alone: 60 patients underwent TAE with gelatin sponge (GS) that contained anticancer agents (protocol 1); 78, TAE with GS and iodized oil mixed with anticancer agents (protocol 2); and 159, TAE with iodized oil with anticancer agents (protocol 3). A Cox proportional hazard model was used to analyze prognostic factors.RESULTS: In the randomized group (n = 272), survival rates for protocols 1, 2, and 3 were 80.4%, 86.3%, and 65.9%, respectively, at 1 year. Findings of analysis of prognostic factors showed that extrahepatic metastases, ascites, tumor extension, and icterus were the important factors.CONCLUSION: TAE with GS was superior to TAE without GS. Patient characteristics were important factors for survival.