Morphological changes in the junctional complex of cells in the arachnoid layer of the rat after cold injury.
Morphological changes in the junctional complex of cells in the arachnoid layer of the rat after cold injury.
复制标题
冷损伤后大鼠蛛网膜层细胞连接复合体的形态变化。
DOI：
10.1007/bf00218887
复制
发表时间：
1989
影响因子：
3.6
通讯作者：
Goss,G
中科院分区：
文献类型：
--
作者：
Anders,JJ;Goss,G
经颅冷损伤脑背表面后60 min，用冷冻断裂电镜检查2周龄大鼠大脑皮层外蛛网膜层细胞的连接复合体。损伤后30分钟内，在一些蛛网膜细胞的正常连接复合体中发现了具有连接形成和/或连接破坏的形态特征的间隙和紧密连接区域。损伤后60 min内，所有蛛网膜细胞均出现紧密连接，其特征为闭合小带渗漏较少。这些形态学特征包括紧密连接股的数量和股间解剖结构的数量增加。间隙连接散布在紧密的连接链之间，并且许多完全被链包围。脑损伤后紧密连接的数量和复杂性增加可能是维持脑脊液-血硬脑膜屏障的形态学基础。
The junctional complexes of cells in the outer arachnoid layer overlying the cerebral cortex of 2-week-old rats were examined with freeze-fracture electron microscopy up to 60 min after transcranial cold injury to the dorsal surface of the brain. Within 30 min after injury, areas of gap and tight junctions with morphological features characteristic of junction formation and/or junction disruption were found scattered among normal junctional complexes in some arachnoid cells. Within 60 min after injury, tight junctions with features typical of less leaky zonulae occludentes were present in all arachnoid cells examined. These morphological features include increases in the number of tight junctional strands and the number of strand-to-strand anatomoses. Gap junctions were interspersed among the tight junctional strands, and many were completely encircled by the strands. The increase in the number and complexity of the tight junctional strands in response to brain injury may be the morphological basis for the maintenance of the cerebrospinal fluid-blood dural barrier.