Attributable risks for hepatocellular carcinoma in Northern Italy
Attributable risks for hepatocellular carcinoma in Northern Italy
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DOI：
10.1016/s0959-8049(96)00500-x
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发表时间：
1997-04-01
影响因子：
8.4
通讯作者：
Franceschi, S
中科院分区：
文献类型：
--
作者：
Braga, C;LaVecchia, C;Franceschi, S
肝细胞癌（HCC）的人群归因风险（ARs）与低教育水平、大量饮酒、低蔬菜和水果摄入量、肝炎史、糖尿病、肝硬化和口服避孕药的使用有关，使用的数据来自1984年至1993年在意大利北部进行的一项病例对照研究。病例为组织学或血清学证实HCC的320例患者（235例男性，85例女性），对照组为1408例患者（1031例男性，377例女性），这些患者因急性、非肿瘤性或非消化道疾病（与任何已知或可能的原发性肝癌危险因素无关）入院。蔬菜和水果摄入量低占40%，受教育程度低占31%，肝硬化占18%，肝炎占16%，糖尿病占8%，大量饮酒占7%。这些因素加在一起解释了74%的肝细胞癌病例。与女性相比，男性在肝硬化（21%比11%）、糖尿病（10%比2%）和重度饮酒（9%比1%）方面的ar更高。所有因素加在一起导致HCC的比例男性为78%，女性为67%。因此，即使关于肝炎和饮食因素的现有信息有限，而且估算的AR是基于一些武断的假设，原则上，现有的知识可以将意大利的疾病负担从3300例男性死亡减少到约750例，将女性死亡从1600例减少到约500例。1997爱思唯尔科学有限公司
The population attributable risks (ARs) for hepatocellular carcinoma (HCC) were estimated in relation to low education level, heavy alcohol consumption, low vegetable and fruit intake, history of hepatitis, diabetes, liver cirrhosis and oral contraceptive use, using data from a case-control study conducted between 1984 and 1993 in Northern Italy. Cases were 320 patients (235 males and 85 females) with histologically or serologically confirmed HCC, and controls were 1408 patients (1031 males and 377 females) admitted to the same network of hospitals for acute, non-neoplastic or non-digestive tract conditions, unrelated to any of the known or likely risk factors for primary liver cancer. The ARs were 40% for low vegetable and fruit consumption, 31% for low education, 18% for liver cirrhosis, 16% for hepatitis, 8% for diabetes and 7% for heavy alcohol consumption. Together, these factors explained 74% of hepatocellular cancer cases. Compared with females, males had higher ARs for cirrhosis (21% versus 11%), diabetes (10% versus 2%) and heavy alcohol consumption (9% versus 1%). The percentage of HCC attributable to all factors considered together was 78% for males and 67% for females. Thus, even if available information on hepatitis and dietary factors was limited, and the AR estimates were based on several arbitrary assumptions, available knowledge could, in principle, reduce the burden of the disease in Italy from 3300 deaths to approximately 750 for males, and from 1600 to approximately 500 for females. (C) 1997 Elsevier Science Ltd.