Maternal body burden of organochlorine pesticides and dioxins.
Maternal body burden of organochlorine pesticides and dioxins.
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有机氯农药和二恶英的母体负担。
DOI：
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发表时间：
1999
影响因子：
1.6
通讯作者：
Junya Nagayama
中科院分区：
文献类型：
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作者：
R. Nakagawa;H. Hirakawa;Takao Iida;T. Matsueda;Junya Nagayama
为了调查日本妇女体内有机氯农药和二恶英的负担，1994年、1995年和1996年分别从41名母亲、42名母亲和42名母亲身上采集了125份牛奶样本。在125份样本中，82份来自初产妇(第一次分娩)，43份来自经产母亲(第二次或以后分娩)。采用毛细管气相色谱-电子捕获检测法，检测出母乳中的主要氯农药为乙型六氯环己烷和p，p‘-DDE。初产妇母乳中β-六氯环己烷和p，p‘-DDE平均含量分别为475和368 ng/g脂肪，经产妇母乳中分别为314和259 ng/g脂肪，全母乳中分别为420和330 ng/g脂肪。狄氏剂、七环氧化合物、环氧氯丹、反式氯丹和顺式氯丹的平均检出量分别为3、4、34、41和5 ng/g脂肪。通过高分辨气相色谱-质谱仪检测，所有样品中都检测到二恶英。初产妇乳汁中总多氯二苯并-对二恶英(PCDD)、总多氯二苯并呋喃(PCDF)、总PCDD+PCDF、总共面多氯联苯(CoPCB)和总二恶英平均水平分别为10.0、7.8、17.7、9.9和27.5TEQ(毒性当量)pg/g脂肪，多胎母乳分别为7.0、5.8、12.8、7.3和20.1TEQ pg/g脂肪；母乳中脂肪含量分别为8.9、7.1、16.1、8.9和25.0TEQ pg/g。在初产妇母乳中，β-六氯环己烷、p，p‘-DDE、总PCDD-TEQ、总PCDF-TEQ、总CoPCB-TEQ和总TEQ之间存在显著的相关性，p，p’-DDE与总PCDF-TEQ之间的相关性较小。除了总的钴-多氯联苯-TEQ，这些分析物的水平也随着母亲的年龄而显著增加。对于与饮食习惯的相关性，唯一正相关的是总PCDF-TEQ与鱼的摄入量。
To investigate the body burden of organochlorine pesticides and dioxins in Japanese women, 125 milk samples were collected from 41 mothers in 1994, 42 in 1995, and 42 in 1996. Of the 125 samples, 82 were from primipara mothers (first delivery) and 43 were from multipara mothers (second or later delivery). By using capillary gas chromatography with electron capture detection, beta-HCH and p,p'-DDE were detected as the major chlorine pesticides in human milk. Average levels of beta-HCH and p,p'-DDE were 475 and 368 ng/g lipid, respectively, in primipara breast milk, 314 and 259 ng/g lipid in multipara breast milk, and 420 and 330 ng/g lipid in total breast milk. Dieldrin, heptachor epoxide, oxychlordane, trans-chlordane, and cis-chlordane were detected at lower average levels of 3, 4, 34, 41, and 5 ng/g lipid, respectively. By using high-resolution gas chromatography with mass spectrometric detection, dioxins were detected in all samples. Average levels of total polychlorinated dibenzo-p-dioxin (PCDD), total polychlorinated dibenzofuran (PCDF), total PCDD + PCDF, total coplanar polychlorinatedbiphenyl (CoPCB), and total dioxin were 10.0, 7.8, 17.7, 9.9, and 27.5 TEQ (toxic equivalent) pg/g lipid, respectively, in primipara breast milk; 7.0, 5.8, 12.8, 7.3, and 20.1 TEQ pg/g lipid in multipara breast milk; and 8.9, 7.1, 16.1, 8.9, and 25.0 TEQ pg/g lipid in total breast milk. In primipara breast milk, significant correlations were found among levels of beta-HCH, p,p'-DDE, total PCDD-TEQ, total PCDF-TEQ, total CoPCB-TEQ, and total TEQ except for less correlation between p,p'-DDE and total PCDF-TEQ. Levels of these analytes also significantly increased depending on mother's age, except for total Co-PCB-TEQ. For the correlation with food habit, the only positive correlation was between total PCDF-TEQs and fish intake.