The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse
The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse
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DOI：
10.1016/j.bbrc.2004.12.137
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发表时间：
2005-03-04
影响因子：
3.1
通讯作者：
Kamps, JAAM
中科院分区：
文献类型：
--
作者：
Yan, XD;Kuipers, F;Kamps, JAAM
我们评价了载脂蛋白E(ApoE)在载脂蛋白E缺陷小鼠肝细胞清除中性和负电荷脂质体中的作用。在apoE缺陷小鼠和野生型小鼠中，负电荷脂质体的清除速度相同；而在apoE缺陷小鼠中，中性脂质体的清除速度要慢3.6倍。载脂蛋白E缺乏并不影响肝脏对负电荷脂质体的摄取，但使中性脂质体的摄取量降低5倍。在apoE缺陷的小鼠中，肝细胞对中性脂质体的摄取减少了20倍；而带负电荷的脂质体的摄取保持不变。我们得出结论，肝细胞摄取中性脂质体几乎完全是由载脂蛋白E介导的。(C)2005年爱思唯尔有限公司。版权所有。
We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively charged liposomes were cleared at identical rates in apoE-deficient and wild-type mice; neutral liposomes were cleared at a 3.6-fold slower rate in apoE-deficient mice. ApoE deficiency did not affect hepatic uptake of negatively charged liposomes but lowered that of neutral liposomes >5-fold. Hepatocyte uptake of neutral liposomes was reduced >20-fold in apoE-deficient mice; that of negatively charged liposomes remained unchanged. We conclude that uptake of neutral liposomes by hepatocytes is nearly exclusively apoE-mediated. (C) 2005 Elsevier lnc. All rights reserved.