Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction
Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction
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DOI：
10.1016/j.bbi.2010.08.001
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发表时间：
2011-01-01
影响因子：
15.1
通讯作者：
Kerkhofs, Myriam
中科院分区：
文献类型：
--
作者：
Faraut, Brice;Boudjeltia, Karim Zouaoui;Kerkhofs, Myriam
了解睡眠和免疫系统之间的相互作用可能有助于了解为什么睡眠时间短与负面健康结果有关。因此，我们研究了睡眠限制后小睡和延长恢复睡眠对免疫和炎症系统以及嗜睡的影响。在一个基线夜晚之后，健康的年轻男性睡了2个小时的夜晚，然后是标准的8个小时的恢复之夜（n = 12），30分钟的午睡（下午1点）。除了8小时恢复夜（n = 10）或10小时延长恢复夜（n = 9）之外。对照组连续睡3个8小时的夜晚（n = 9）。受试者接受连续脑电图多导睡眠描记术，每天上午7点采血。研究白细胞、炎症和动脉粥样硬化生物标志物（高敏C反应蛋白、白细胞介素-8、髓过氧化物酶、纤维蛋白原和载脂蛋白ApoB/ApoA）、睡眠模式和嗜睡。对照组的所有参数均保持不变。在睡眠限制后，白细胞和（在白细胞亚群中）中性粒细胞计数增加，这种效应在8小时恢复睡眠后持续存在，但是，在小睡或10小时恢复睡眠的受试者中，这些值几乎恢复到基线。除了睡眠限制后髓过氧化物酶水平升高外，炎症和动脉粥样硬化形成生物标志物没有变化。在小睡和延长睡眠恢复条件下，睡眠限制后增加的嗜睡被逆转得更好。午睡后唾液皮质醇立即下降。我们的研究结果表明，在恢复性睡眠之前的午睡或延长的夜间睡眠提供的睡眠限制后的额外恢复性睡眠可以提高警觉性，并使白细胞计数恢复到基线值。(C)2010年爱思唯尔公司All rights reserved.
Understanding the interactions between sleep and the immune system may offer insight into why short sleep duration has been linked to negative health outcomes. We, therefore, investigated the effects of napping and extended recovery sleep after sleep restriction on the immune and inflammatory systems and sleepiness. After a baseline night, healthy young men slept for a 2-h night followed by either a standard 8-h recovery night (n = 12), a 30-min nap (at 1 p.m.) in addition to an 8-h recovery night (n = 10), or a 10-h extended recovery night (n = 9). A control group slept 3 consecutive 8-h nights (n = 9). Subjects underwent continuous electroencephalogram polysomnography and blood was sampled every day at 7 a.m. Leukocytes, inflammatory and atherogenesis biomarkers (high-sensitivity C-reactive protein, interleukin-8, myeloperoxidase, fibrinogen and apolipoproteins ApoB/ApoA), sleep patterns and sleepiness were investigated. All parameters remained unchanged in the control group. After sleep restriction, leukocyte and - among leukocyte subsets - neutrophil counts were increased, an effect that persisted after the 8-h recovery sleep, but, in subjects who had a nap or a 10-h recovery sleep, these values returned nearly to baseline. Inflammatory and atherogenesis biomarkers were unchanged except for higher myeloperoxidase levels after sleep restriction. The increased sleepiness after sleep restriction was reversed better in the nap and extended sleep recovery conditions. Saliva cortisol decreased immediately after the nap. Our results indicate that additional recovery sleep after sleep restriction provided by a midday nap prior to recovery sleep or a sleep extended night can improve alertness and return leukocyte counts to baseline values. (C) 2010 Elsevier Inc. All rights reserved.