DIET AND CHRONIC ATROPHIC GASTRITIS - A CASE CONTROL STUDY
DIET AND CHRONIC ATROPHIC GASTRITIS - A CASE CONTROL STUDY
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DOI：
10.1093/jnci/76.4.621
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发表时间：
1986-04-01
影响因子：
10.3
通讯作者：
TANNENBAUM, SR
中科院分区：
文献类型：
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作者：
FONTHAM, E;ZAVALA, D;TANNENBAUM, SR
在路易斯安那州南部[美国]的一个高风险黑人人群中进行了一项以医院为基础的胃癌前病变病例对照研究。93例经活检证实的晚期慢性萎缩性胃炎患者与两个对照组进行比较：胃镜检查门诊组和普通医院入院组。饮食病例对照差异表明，与水果和蔬菜摄入量和饮食维生素C和与牛奶消费相关的风险升高的保护作用。与水果、蔬菜和维生素C消费相关的保护作用与胃癌的发现和胃内亚硝化的病因学假设一致。两倍的风险增加与吸烟有关。对接受胃镜检查的受试者进行胃液pH值、NO3-和NO2-测定，并将这一高风险的美国人群与风险程度更高的哥伦比亚人群进行比较;后者的NO3-和NO2-水平更高。pH值升高与胃病变严重程度增加相关。pH值和NO2-浓度水平显著相关（P < .0005）;然而，在路易斯安那州，与pH值升高相关的NO2-浓度的巨大差异与组织病理学严重程度无关。在这两个人群中，NO3-浓度与病变严重程度的趋势不同。
A hospital-based case-control study of gastric cancer precursor lesions was conducted in a high-risk black population in southern Louisiana [USA]. Ninety-three subjects with biopsy-proved advanced chronic atrophic gastritis were compared to two control series: a gastroscopy clinic series and a general hospital-admission series. Dietary case-control differences indicated a protective effect associated with fruit and vegetable intake and with dietary vitamin C and a risk elevation associated with milk consumption. The protective effect associated with consumption of fruits, vegetables, and vitamin C is consistent with findings for gastric cancer and with the etiologic hypothesis of intragastric nitrosation. A twofold increased risk was associated with cigarette smoking. Gastric juice pH, NO3-, and NO2- were determined for subjects undergoing gastroscopy, and comparisons were made between this high-risk U.S. group and a Colombian population with a much greater magnitude of risk; the latter had higher NO3- and NO2- levels. An increase in pH was associated with increasing severity of gastric lesions. Levels of pH and NO2- concentration were significantly correlated (P < .0005); however, in Louisiana the large difference in NO2- concentration associated with pH elevation is not associated with histopathologic severity. Divergent trends with severity of lesions for NO3- concentration were seen in the two populations.