The changing prevalence of autism in California
The changing prevalence of autism in California
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DOI：
10.1023/a:1015453830880
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发表时间：
2002-06-01
影响因子：
3.9
通讯作者：
Selvin, S
中科院分区：
文献类型：
--
作者：
Croen, LA;Grether, JK;Selvin, S
我们对八个连续的加州出生队列进行了一项基于人群的研究，以检查检测的改进和诊断的变化对观察到的自闭症患病率增加的影响程度。1987-1994年出生的自闭症儿童是由负责协调发展障碍个人服务的全州机构确定的。为了评估诊断替代的作用，还调查了无自闭症的智力迟钝的流行趋势。在加州出生的4590333名儿童中，共有5038名儿童患有完全综合征自闭症，患病率为11.0 / 10000。在研究期间，患病率从每万人5.8人增加到14.9人，绝对变化为每万人9.1人。增加的模式不受母亲年龄、种族/民族、教育程度、儿童性别或多胞胎的影响。在同一时期，无自闭症的智力迟钝患病率从28.8 / 10000下降到19.5 / 10000，绝对变化为9.3 / 10000。这些数据表明，检测的改进和诊断的改变是观察到的自闭症增加的原因；发病率是否真的有所上升还不得而知。
We conducted a population-based study of eight successive California births cohorts to examine the degree to which improvements in detection and changes in diagnosis contribute to the observed increase in autism prevalence. Children born in 1987-1994 who had autism were identified from the statewide agency responsible for coordinating services for individuals with developmental disabilities. To evaluate the role of diagnostic substitution, trends in prevalence of mental retardation without autism were also investigated. A total of 5038 children with full syndrome autism were identified from 4,590,333 California births, a prevalence of 11.0 per 10,000. During the study period, prevalence increased from 5.8 to 14.9 per 10,000, for an absolute change of 9.1 per 10,000. The pattern of increase was not influenced by maternal age, race/ethnicity, education, child gender, or plurality. During the same period, the prevalence of mental retardation without autism decreased from 28.8 to 19.5 per 10,000, for an absolute change of 9.3 per 10,000. These data suggest that improvements in detection and changes in diagnosis account for the observed increase in autism; whether there has also been a true increase in incidence is not known.