Prenatal opiate exposure attenuates LPS-induced fever in adult rats: role of interleukin-1beta.
Prenatal opiate exposure attenuates LPS-induced fever in adult rats: role of interleukin-1beta.
复制标题
产前阿片暴露可减轻成年大鼠 LPS 引起的发热：白细胞介素 1β 的作用。
DOI：
10.1016/j.brainres.2006.11.044
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发表时间：
2007
期刊：
影响因子：
2.9
通讯作者：
Schrott,LisaM
中科院分区：
文献类型：
--
作者：
Hamilton,KathrynL;Franklin,La'TonyiaM;Roy,Sabita;Schrott,LisaM
Much is known about the immunomodulatory effects of opiate exposure and withdrawal in adult rats. However, little research has delved into understanding the immunological consequences of prenatal opiate exposure and postnatal withdrawal. The purpose of the current study was to measure changes in responding to immune stimulation in adult rats following prenatal opiate exposure. Further, we sought to characterize the role of interleukin (IL)-1β in these changes. Following prenatal exposure to the long-acting opiate l-alpha-acetylmethadol (LAAM), adult male and female rats were assessed for their fever response to lipopolysaccharide (LPS). Blood and tissue samples were collected to measure circulating IL-1β and IL-1β protein in the hypothalamus and spleen. Prenatal LAAM exposure resulted in a blunted fever response to LPS injection without any changes in basal body temperature or in response to saline injection. Circulating IL-1β was not affected by prenatal LAAM exposure, nor was IL-1β protein in the spleen. Interestingly, mature IL-1β protein was elevated in the hypothalamus of prenatally LAAM-treated rats. These results indicate that prenatal opiate exposure blunts the fever response of adult offspring. Direct action of IL-1β is likely not the cause of the dysfunction reported here. However, alterations in signaling mechanisms downstream from IL-1β may play a role in the altered fever response in adult rats treated prenatally with opiates.
