Infection with human papillomavirus and HIV among young women in Kampala, Uganda
Infection with human papillomavirus and HIV among young women in Kampala, Uganda
复制标题
DOI：
10.1086/526792
复制
发表时间：
2008-02-15
影响因子：
6.4
通讯作者：
Weiderpass, Elisabete
中科院分区：
文献类型：
--
作者：
Banura, Cecily;Franceschi, Silvia;Weiderpass, Elisabete
背景。有关年轻女性中不同类型人乳头瘤病毒 (HPV) 宫颈感染流行情况的信息对于支持在乌干达引进 HPV 疫苗至关重要。方法。横断面调查结果来自一项队列研究，该研究涉及 1,275 名性活跃的 12-24 岁女性，他们在乌干达坎帕拉的一家青少年诊所寻求医疗服务。我们通过使用高灵敏度聚合酶链式反应检测评估了 39 种 HPV 类型的存在。结果。 HPV感染率为74.6%，人类免疫缺陷病毒感染率为8.6%。 51.4% 的女性发现高危 HPV 类型，最常检测到的高危类型依次为 HPV 52、51、18 和 16。 HPV 16 和/或 18 阳性的女性中，总共 71.8% 也感染了其他高危 HPV 类型。与 HIV 阴性女性相比，HIV 阳性女性的 HPV 感染率（87.8% vs 73.2%）和多种感染率（64.6% vs 37.3%）更高。第三部门的就业、一生性伴侣的数量、同时怀孕和尖锐湿疣的存在与 HPV 阳性显着相关。结论。乌干达坎帕拉年轻女性的 HPV 感染率很高。青少年诊所提供了监测 HPV 疫苗影响的机会，并有可能发现最近性活跃的未接种疫苗的年轻女性。
Background. Information on the prevalence of cervical infection with different human papillomavirus (HPV) types among young women is essential to support the introduction of HPV vaccine in Uganda.Methods. Cross-sectional findings are presented from a cohort study of 1,275 sexually active women aged 12-24 years seeking health services at a clinic for teenagers in Kampala, Uganda. We assessed the presence of 39 HPV types by use of highly sensitive polymerase chain reaction assays.Results. The prevalence of HPV infection was 74.6%, and the prevalence of human immunodeficiency virus infection was 8.6%. High-risk HPV types were found in 51.4% of women, and the most frequently detected high-risk types were, in decreasing order, HPV 52, 51, 18, and 16. A total of 71.8% of the women who were positive for HPV 16 and/or 18 were also infected with other high-risk HPV types. HIV-positive women had a higher prevalence of HPV infection (87.8% vs 73.2%) and of multiple-type infections (64.6% vs 37.3%), compared with HIV-negative women. Employment in the tertiary sector, lifetime number of sexual partners, concurrent pregnancy, and the presence of genital warts were significantly associated with HPV positivity.Conclusions. The prevalence of HPV infection is high among young women in Kampala, Uganda. Clinics for teenagers provide an opportunity to monitor the impact of HPV vaccines and, possibly, to catch up unvaccinated young women who have recently become sexually active.