Cross section data for the production of the positron emitting niobium isotope 90Nb via the 90Zr(p, n)-reaction
Cross section data for the production of the positron emitting niobium isotope 90Nb via the 90Zr(p, n)-reaction
复制标题
DOI：
10.1524/ract.2002.90.1_2002.1
复制
发表时间：
2002-01-01
影响因子：
1.8
通讯作者：
Qaim, SM
中科院分区：
文献类型：
--
作者：
Busse, S;Rösch, F;Qaim, SM
放射性同位素 Nb-90 的衰变具有 53% 的正电子分支和相对较低的 β(+) 能量，即 E-mean = 0.66 MeV 和 E-max = 1.5 MeV。其半衰期为 14.6 小时，使其特别适合使用正电子发射断层扫描对具有缓慢分布动力学的生物过程进行定量研究。为了优化其生产，通过堆叠箔技术，使用 Zr-nat 和 99.22% 富集的 (ZrO2)-Zr-90 作为目标，在 7.5 至 19 MeV 的质子能量范围内研究了 Zr-90(p, xn) 过程的激发函数。 Nb-90 的粗目标产率是根据测量的激发函数计算出来的，并通过实验进行了验证。通过 Zr-90(p, n) 工艺生产 Nb-90 的最佳能量范围为 E-p = 17 --> 7 MeV，产量为 600 MBq Nb-90/muA h。使用 Zr-nat 通过实验确定了 E-p = 17.6 --> 8.1 MeV 能量范围内 Nb-90 的产率和放射性核素纯度。 EOB 后 4 小时，Nb-90 的产量为 290 MBq/muA h，其放射性核素纯度大于或等于 95%。
The radioisotope Nb-90 decays with a positron branching of 53% and a relatively low beta(+)-energy of E-mean = 0.66 MeV and E-max = 1.5 MeV. Its half-life of 14.6 h makes it especially promising for quantitative investigation of biological processes with slow distribution kinetics using positron emission tomography. To optimise its production, the excitation functions of Zr-90(p, xn)-processes were studied over the proton energy range of 7.5 to 19 MeV via the stacked-foil technique using both Zr-nat and 99.22% enriched (ZrO2)-Zr-90 as targets. Thick target yields of Nb-90 were calculated from the measured excitation functions and were verified experimentally. The optimum energy range for the production of Nb-90 via the Zr-90(p, n)-process was found to be E-p = 17 --> 7 MeV, with a yield of 600 MBq Nb-90/muA h. The yield and radionuclidic purity of Nb-90 over the energy range of E-p = 17.6 --> 8.1 MeV were determined experimentally using Zr-nat. At 4 h after EOB the yield of Nb-90 was found to be 290 MBq/muA h and its radionuclidic purity greater than or equal to 95%.