Headless Myo10 is a regulator of microtubule stability during neuronal development
Headless Myo10 is a regulator of microtubule stability during neuronal development
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Headless Myo10 是神经元发育过程中微管稳定性的调节剂
DOI：
10.1111/jnc.13238
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发表时间：
2015-10-01
影响因子：
4.7
通讯作者：
Zhu, Xiaojuan
中科院分区：
文献类型：
--
作者：
Yu, Huali;Sun, Dong;Zhu, Xiaojuan
稳定的微管是神经元形态发生和迁移所必需的。然而，其潜在机制尚未完全明晰。在本研究中，我们证实了肌球蛋白X（Myo10），由全长肌球蛋白X（fMyo10）和无头肌球蛋白X（hMyo10）组成，对轴突发育至关重要。fMyo10参与轴突伸长，而hMyo10通过稳定微管，对Tau - 1阳性轴突的形成起着关键作用。此外，体内研究表明，hMyo10介导的微管稳定性对哺乳动物大脑皮层中的神经元迁移和树突分支均有深远影响。综上所述，我们的研究结果表明，hMyo10通过调节微管稳定性，在体外和体内均参与了神经元发育过程。
Stabilized microtubules are required for neuronal morphogenesis and migration. However, the underlying mechanism is not fully understood. In this study, we demonstrate that myosin X (Myo10), which is composed of full-length myosin X (fMyo10) and headless myosin X (hMyo10), is important for axon development. fMyo10 is involved in axon elongation, whereas hMyo10 is critical for Tau-1 positive axon formation through stabilizing microtubules. Furthermore, invivo studies reveal that hMyo10-mediated microtubule stability has a profound effect on both neuronal migration and dendritic arborization in the mammalian cerebral cortex. Taken together, our findings suggest that hMyo10 is involved in neuronal development both invitro and invivo by regulating microtubule stability.