Psychopathy as a disorder of the moral brain: Fronto-temporo-limbic grey matter reductions demonstrated by voxel-based morphometry
Psychopathy as a disorder of the moral brain: Fronto-temporo-limbic grey matter reductions demonstrated by voxel-based morphometry
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DOI：
10.1016/j.neuroimage.2007.12.054
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发表时间：
2008-04-15
期刊：
影响因子：
5.7
通讯作者：
Moll, Jorge
中科院分区：
文献类型：
--
作者：
de Oliveira-Souza, Ricardo;Hare, Robert D.;Moll, Jorge
在过去的几年里，对精神病的神经生物学的理解已经取得了重大进展，但对这种疾病背后的神经解剖异常的分布和程度仍然知之甚少。目前还不清楚精神病的不同维度（e。例如，在一个实施例中，情感冷漠，反社会行为）对应于大脑不同区域的结构异常。我们测试了以下假设：（1）精神病与大脑中支持道德行为的区域的灰质减少有关;（2）精神病的严重程度与结构异常的程度有关。采用优化的基于体素的形态测量法和精神病检查表（PCL：SV）的筛选版本，调查了15名社区精神病患者与高PCL：SV评分的匹配样本，和15名健康的正常志愿者。分析控制了总灰质、白色物质和脑脊液体积。在患者的额极、眶额和前颞皮质、上级颞沟区域和颞叶观察到灰质减少。结构异常的程度显着相关的人际/情感维度的精神病。高精神病评分患者的灰质减少模式包括一个分布式额颞叶网络，在道德情感和行为中起着关键作用。(C)2008年爱思唯尔公司All rights reserved.
Major advances have been made in the understanding of the neurobiology of psychopathy in the past years, yet the distribution and extent of neuroanatomical abnormalities underlying the disorder are still poorly known. It is also unclear if different dimensions of the construct of psychopathy (e. g., emotional callousness, antisocial behavior) correspond to structural abnormalities in distinct regions of the brain. We tested the following hypotheses: (1) psychopathy is related to grey matter reductions in regions of the brain that underlie moral conduct and (2) the severity of psychopathy is related to the degree of structural abnormalities. Optimized voxel-based morphometry and the screening version of the Psychopathy Checklist (PCL: SV) were employed to investigate a matched sample of 15 community psychiatric patients with high PCL: SV scores, and 15 healthy normal volunteers. The analyses controlled for total grey matter, white matter and cerebrospinal fluid volumes. Grey matter reductions were observed in the frontopolar, orbitofrontal and anterior temporal cortices, superior temporal sulcus region, and insula of the patients. The degree of structural abnormalities was significantly related to the interpersonal/affective dimension of psychopathy. The pattern of grey matter reductions in patients with high psychopathy scores comprised a distributed fronto-temporal network which plays a critical role in moral sensibility and behavior. (C) 2008 Elsevier Inc. All rights reserved.