Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis: Impact of Early Response to 4 Weeks of Treatment
Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis: Impact of Early Response to 4 Weeks of Treatment
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DOI：
10.1159/000367737
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发表时间：
2015-01-01
期刊：
影响因子：
13.8
通讯作者：
Lin, Shi-Ming
中科院分区：
文献类型：
--
作者：
Lin, Chen-Chun;Hung, Chien-Fu;Lin, Shi-Ming
目的：探讨肝动脉输注化疗（HAIC）早期反应（ER）对晚期肝癌合并门静脉肿瘤血栓形成（PVTT）患者预后的影响。方法：纳入39例低剂量顺铂、5-氟尿嘧啶（5FU）、亚叶酸素联合HAIC的患者。一个疗程为每周治疗5天，休息2天，连续4周。ER分为完全缓解、部分缓解或轻微缓解，并根据世界卫生组织的标准确定，在HAIC第一个疗程后1周内进行动态计算机断层扫描。结果：13例（33%）患者获得急诊。这13名ER患者中有12名（92.3%）达到了比26名非早期应答者（ner）中除1名（3.8%）外的所有患者更高的总体反应（p . 476）
Aim: The aim of the study was to investigate the impact of early response (ER) to hepatic arterial infusion chemotherapy (HAIC) on outcomes of patients with advanced hepatocellular carcinoma (HCC) complicated with major portal vein tumor thrombosis (PVTT). Methods: Thirty-nine patients receiving HAIC with low-dose cisplatin, 5-fluorouracil (5FU), and leucovorin were enrolled. One course of HAIC consisted of 5 days of treatment and 2 days rest per week for 4 consecutive weeks. ER was categorized as complete response, partial response, or minor response and was determined by World Health Organization criteria with dynamic computed tomography findings performed within 1 week after the first course of HAIC. Results: Thirteen (33%) patients achieved an ER. Twelve (92.3%) of these 13 ER patients achieved a higher overall response than all but one (3.8%) of the 26 non-early responders (NERs) (p