Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s).
Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s).
复制标题
推测 CD4(-)8( ) 肠道来源的 T 细胞之间的谱系关系及其作用。
作者：
P. Poussier;M. Julius
小鼠肠粘膜的胸腺非依赖性T淋巴细胞生成能力已经建立。Cryptopatches现在已经被确定为肠道衍生T细胞的难以捉摸的前体的位置。这些隐补丁细胞已显示产生表达TCR γ δ或TCR α的肠T细胞。在这里，我们讨论的作用，MHC的发展和选择肠源性T细胞。通过对表达转基因TCR α的动物中iIEL选择的分析，在存在或不存在p56（lck）的情况下，我们讨论了CD 4（-）8（+）iIEL亚群之间的谱系关系及其可能的功能。
The thymus-independent T lymphopoietic capacity of the murine intestinal mucosa has been established. Cryptopatches have now been identified as the location of the elusive precursors for gut-derived T cells. These cryptopatch cells have been shown to give rise to intestinal T cells expressing either TCRgammadelta or TCRalphabeta. Here we discuss the role of MHC in the development and selection of gut-derived T cells. Through the analysis of iIEL selection in animals expressing a transgenic TCRalphabeta, in the presence or absence of p56(lck), we discuss lineage relationships among CD4(-)8(+) iIEL subsets, and their possible function(s).
无胸腺放射嵌合体中表达膜 T 细胞受体的骨髓来源肠上皮 T 细胞的分化和功能成熟。
DOI：
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发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Mosley,RL;Styre,D;Klein,JR
通讯作者：
Klein,JR
影响因子：
32.4
作者：
VANOERS, NSC;KILLEEN, N;WEISS, A
通讯作者：
WEISS, A