Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease
Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease
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DOI：
10.1016/j.rmed.2008.01.010
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发表时间：
2008-06-01
影响因子：
4.3
通讯作者：
Kucuk, Omer
中科院分区：
文献类型：
--
作者：
Kirkil, Gamze;Muz, Mehmet Hamdi;Kucuk, Omer
氧化应激和抗氧化能力之间的不平衡被认为在慢性阻塞性肺疾病（COPD）的发病机制中发挥着重要作用。然而，关于稳定期慢性阻塞性肺病患者和补锌效果的研究尚缺乏。我们研究了吡啶甲酸锌补充剂对稳定期 COPD 患者氧化应激和肺功能测试 (PFT) 的影响。该研究包括 30 名慢性阻塞性肺病患者和 15 名年龄和性别相匹配的健康非吸烟者。测量了他们的基线肺活量测定、血浆丙二醛（MDA）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和锌水平。每天补充 22 毫克吡啶甲酸锌 8 周后，重复所有参数。 COPD 组基线时的平均 MDA 水平高于对照组（0.51 +/- 0.15 vs 0.39 +/- 0.15 nmol/mL，p = 0.037），而 SOD（0.16 +/- 0.022 vs 0.20 +/- 0.04 U/mL，p = 0.000）、CAT（14.79 +/- 3.03 vs与对照组相比，患者的锌水平（17.37 +/- 2.60 k/mL，p=0.008）和锌水平（77.33 +/- 4.29 vs 91.45 +/- 3.95 mg/dL，p = 0.000）较低。补充锌八周后，平均 SOD (p = 0.029) 和锌水平 (p = 0.029) 显着增加
An imbalance between oxidative stress and antioxidant capacity is thought to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, studies in regard to stable COPD patients and effect of zinc supplementation are lacking. We investigated the effects of zinc picolinate supplementation on the oxidant stress, and pulmonary function tests (PFTs) of patients with stable COPD. Thirty patients with COPD, and 15 healthy non-smokers who were matched for age and sex were included in the study. Their baseline spirometry, plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and zinc levels were measured. All parameters were repeated after 8 weeks of supplementation with 22 mg of zinc picolinate daily. The mean MDA levels in the COPD group at baseline were higher than controls (0.51 +/- 0.15 vs 0.39 +/- 0.15 nmol/mL, p = 0.037), while SOD (0.16 +/- 0.022 vs 0.20 +/- 0.04 U/mL, p = 0.000), CAT (14.79 +/- 3.03 vs 17.37 +/- 2.60 k/mL, p=0.008) and zinc levels (77.33 +/- 4.29 vs 91.45 +/- 3.95 mg/dL, p = 0.000) were lower in the patients compared to controls. Eight weeks of zinc supplementation produced significant increase in mean SOD (p = 0.029) and zinc levels (p