Evidence against involvement of APC mutation in papillary thyroid carcinoma.
Evidence against involvement of APC mutation in papillary thyroid carcinoma.
复制标题
反对 APC 突变参与甲状腺乳头状癌的证据。
DOI：
10.1016/0959-8049(94)90129-5
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发表时间：
1994
影响因子：
8.4
通讯作者：
D. Wynford‐Thomas
中科院分区：
文献类型：
--
作者：
L. Curtis;A. Wyllie;J. Shaw;G. Williams;A. Rădulescu;C. Demicco;D. Haugen;J. Varhaug;J. Lillehaug;D. Wynford‐Thomas
甲状腺乳头状癌（PTC）是与家族性腺瘤性息肉病（FAP）相关的几种肿瘤之一，FAP是一种遗传性肿瘤综合征，似乎是由APC肿瘤抑制基因的种系突变引起的。在这里，我们调查APC的体细胞突变可能在散发性PTC中发挥作用的可能性。应用单链构象多态性（SSCP）分析方法，对16例PTC及相应正常组织中APC基因突变簇区（MCR）（密码子1286-1513）进行了研究。在任何样品中均未观察到突变证据。我们的结论是，APC突变，至少在MCR，是不是一个重要的因果机制，在散发性PTC。
Papillary thyroid carcinoma (PTC) is one of several tumours associated with familial adenomatous polyposis (FAP), an inherited tumour syndrome which appears to result from germ-line mutation of the APC tumour suppressor gene. Here we investigate the possibility that somatic mutation of APC might play a role in sporadic PTC. 16 cases of PTC together with matched normal tissue were examined by single-strand conformation polymorphism (SSCP) analysis, concentrating on the mutation cluster region (MCR) of the APC gene (codons 1286–1513). No evidence of mutation was observed in any sample. We conclude that APC mutation, at least in the MCR, is not a significant causal mechanism in sporadic PTC.
影响因子：
15.9
作者：
FAGIN, JA;MATSUO, K;KOEFFLER, HP
通讯作者：
KOEFFLER, HP