SYNTHESIS OF SOME BRIDGEHEAD BRIDGEHEAD-DISUBSTITUTED BICYCLO[1.1.1]PENTANES
SYNTHESIS OF SOME BRIDGEHEAD BRIDGEHEAD-DISUBSTITUTED BICYCLO[1.1.1]PENTANES
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DOI：
10.1021/jo00090a015
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发表时间：
1994-06-03
影响因子：
3.6
通讯作者：
TAYLOR, DK
中科院分区：
文献类型：
--
作者：
DELLA, EW;TAYLOR, DK
介绍了多种1，3-二取代双环[1.1.1]戊烷的合成方法，特别着重于溶剂分解研究所需的一系列S-X-取代双环[1.1.1]戊基溴的生成。在桥头的官能团操作很容易在大多数情况下完成的自由基过程中，在某些情况下，转换是通过carbanionic型中间体的影响。
The synthesis of a wide variety of 1,3-disubstituted bicyclo[1.1.1]pentanes is described, with particular emphasis on the generation of a series of S-X-substituted bicyclo[1.1.1]pentyl bromides required for solvolytic studies. Functional group manipulation at the bridgehead was readily accomplished in the majority of cases by radical processes in some instances, transformations were effected via carbanionic-type intermediates.