Yin and yang of interleukin-17 in host immunity to infection.
Yin and yang of interleukin-17 in host immunity to infection.
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DOI：
10.12688/f1000research.10862.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Khader S
中科院分区：
文献类型：
--
作者：
Das S;Khader S
白细胞介素-17 （IL-17）家族细胞因子，如IL-17A和IL-17F，在宿主对细菌、真菌、寄生虫和病毒等多种感染的免疫应答中发挥重要的保护作用。IL-17R信号传导和下游途径介导了参与控制这些病原体的促炎分子的诱导。然而，IL-17的产生也可以介导与感染相关的病理和炎症。在本文中，我们将讨论IL-17在宿主对病原体免疫中的阴阳作用。
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.