Prediction of survival and opportunistic infections in HIV‐infected patients: a comparison of imputation methods of incomplete CD4 counts
Prediction of survival and opportunistic infections in HIV‐infected patients: a comparison of imputation methods of incomplete CD4 counts
复制标题
HIV 感染者的生存率和机会性感染的预测：不完整 CD4 计数的插补方法的比较
作者：
G. Molenberghs;Paige L. Williams;S. Lipsitz
在评估艾滋病毒感染患者死亡或发生机会性感染的风险时，每立方毫米血液中的CD4淋巴细胞数量被广泛认为是预测此类未来事件的最佳可用指标之一。然而，它的有用性是有限的，这是不完整的和可变性的这类CD4测量在随访期间。由于这些限制，对这些数据的分析需要“填充”丢失的测量数据，或者排除没有这些测量数据的患者。我们考虑部分基于来自其他健康状况测量的信息，如血红蛋白，以及感兴趣的事件状况，对CD4值进行多重归因。这些替代的健康状况指标也被认为可能是生存终点的独立预测指标。我们的工作是由参加两个艾滋病临床试验的1530名患者组成的队列推动的。我们将我们的方法与其他策略进行比较，例如基于基线CD4、事件前最后测量的CD4或基于最后一个CD4值的与时间相关的协变量进行风险评估；最后，我们强烈建议进行多次补偿。版权所有©2002 John Wiley&Sons，Ltd.
In evaluating the risk of mortality or development of opportunistic infections in HIV‐infected patients, the number of CD4 lymphocyte cells per cubic millimetre of blood is widely recognized as one of the best available predictors of such future events. However, its usefulness is limited by the incompleteness and variability of such CD4 measurements during follow‐up. Because of these limitations, analysis of such data requires the missing measurements to be ‘filled in’ or the patients without them to be excluded. We consider multiple imputation of CD4 values based partly on information from other health status measures such as haemoglobin, as well as on the event status of interest. These alternative health status measures are also considered as possible independent predictors of survival endpoints. Our work is motivated by a cohort of 1530 patients enrolled in two AIDS clinical trials. We compare our approach to other strategies such as basing evaluation of risk on baseline CD4, the last measured CD4 before an event, or a time‐dependent covariate based on carrying the last CD4 value forward; we conclude with a strong recommendation for multiple imputation. Copyright © 2002 John Wiley & Sons, Ltd.
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DOI：
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发表时间：
1994-03
期刊：
Journal of acquired immune deficiency syndromes
影响因子：
--
作者：
A. Saah;D. Hoover;Yanhua He;Kingsley La;Phair Jp
通讯作者：
A. Saah;D. Hoover;Yanhua He;Kingsley La;Phair Jp
DOI：
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发表时间：
1972
期刊：
--
影响因子：
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作者：
D. Cox
通讯作者：
D. Cox
影响因子：
158.5
作者：
PHAIR, J;MUNOZ, A;SAAH, A
通讯作者：
SAAH, A
影响因子：
1.9
作者：
WEI, GCG;TANNER, MA
通讯作者：
TANNER, MA