A patient with acute myeloid leukemia who developed fatal pneumonia caused by carbapenem-resistant Bacillus cereus
A patient with acute myeloid leukemia who developed fatal pneumonia caused by carbapenem-resistant Bacillus cereus
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DOI：
10.1007/s10156-008-0654-8
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发表时间：
2009-02-01
影响因子：
2.2
通讯作者：
Tamura, Kazuo
中科院分区：
文献类型：
--
作者：
Katsuya, Hiroo;Takata, Tohru;Tamura, Kazuo
蜡样芽孢杆菌是一种严重的细菌性病原体，在贫血患者。B。蜡状芽孢杆菌通常对β-内酰胺类包括青霉素和头孢菌素具有抗性。我们报告一例由B引起的致命性肺炎。在缓解诱导治疗期间，新诊断的急性髓性白血病（AML）患者出现蜡样变。开始使用头孢吡肟治疗发热性中性粒细胞减少症（FN），当发生暴发性肺炎时，改用帕尼培南/倍他米隆。分离菌株不仅对头孢吡肟耐药，而且对帕尼培南/倍他米隆耐药。这是首次报道由碳青霉烯类耐药B引起的暴发性感染。一个贫血病人的蜡状细胞。B。当贫血患者发展为肺炎时，应记住蜡样芽胞杆菌作为经验性治疗的目标。
Bacillus cereus is known as a serious bacterial pathogen in neutropenic patients. B. cereus is often resistant to beta-lactams, including penicillins and cephalosporins. We report a case of fatal pneumonia caused by B. cereus in a patient with newly diagnosed acute myeloid leukemia (AML) during remission induction therapy. Cefepime was started for febrile neutropenia (FN) initially and was switched to panipem/betamipron, when fulminant pneumonia supervened. The isolated strain was resistant not only to cefepime but also to panipenem/betamipron. This is the first report of fulminant infection caused by carbapenem-resistant B. cereus in a neutropenic patient. B. cereus should be kept in mind as a target of empirical treatment when neutropenic patients develop pneumonia.