Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience.
Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience.
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DOI：
10.1097/rhu.0b013e3181b0e910
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Sweiss NJ
中科院分区：
文献类型：
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作者：
Mileti LM;Strek ME;Niewold TB;Curran JJ;Sweiss NJ
结果/讨论 本病例系列包括 15 名 Jo-1 阳性 ILD 和/或肌炎患者。所有患者的主要临床特征总结于表1（参见表，补充数字内容1，http://links.lww.com/RHU/A2）（图1）。随访时间从5个月到13年不等。一名患者在诊断 PM 前 2 个月被诊断出患有相关胸腺瘤。另一位患者在诊断 ILD 前 18 年就被诊断出乳腺癌。其余患者没有恶性肿瘤的证据。已知抗 Jo-1 抗体的存在与 PM 和 DM 患者 ILD 发病率增加有关；然而，它们的预后作用尚不确定。 10, 11 我们从我们的系列中注意到，根据 PFT 和胸部 CT 确定，15 名患者中有 14 名患有 ILD，其中 10 名患者在发病时患有 ILD。我们发现，出现肺部受累的 AA 患者的初始平均用力肺活量低于白人患者（AA 患者预测为 49%，白人患者预测为 75%，P < 0.17）。这似乎并不依赖于获得初始用力肺活量的时间，因为这在两组之间是可比的。
RESULTS/DISCUSSIONFifteen patients with Jo-1 positive ILD and/or myositis were included in this case series. The main clinical characteristics of all the patients are summarized in Table 1 (see Table, Supplemental Digital Content 1, http://links. lww. com/RHU/A2)(Fig. 1). Follow-up ranged from 5 months to 13 years. One patient had an associated thymoma diagnosed 2 months before the diagnosis of PM. Another patient had breast cancer diagnosed 18 years before the diagnosis of ILD. The remainder of the patients had no evidence of malignancy.The presence of anti-Jo-1 antibodies is known to be associated with increased rates of ILD in PM and DM patients; however, their prognostic role is uncertain. 10, 11 We noted from our series that 14 of 15 patients had ILD as determined by PFTs and chest CTs, 10 of whom had ILD at disease onset. We found that the AA patients who presented with pulmonary involvement had lower initial mean FVCs than the white patients (49% predicted in AA, 75% predicted in whites, P 0.17). This did not appear to be dependent on the time to obtaining the initial FVC, as this was comparable between the 2 groups.