Successful chemotherapy for childhood metastatic embryonal cell carcinoma of the testicle: a preliminary report.
Successful chemotherapy for childhood metastatic embryonal cell carcinoma of the testicle: a preliminary report.
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儿童睾丸转移性胚胎细胞癌的成功化疗：初步报告。
DOI：
10.1002/mpo.2950080111
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
A. Bueschen
中科院分区：
文献类型：
--
作者：
C. Holbrook;W. Crist;W. Cain;A. Bueschen
一个儿童与广泛转移成功地治疗化疗单独描述。使用顺铂、长春碱和博来霉素联合化疗一个疗程后，多发性肺转移灶消失。四个疗程的治疗使腹部肿块缩小和肿瘤消毒。化疗开始26个月后，患者良好，停止所有治疗14个月，无疾病或药物相关并发症，肌酐清除率和甲胎蛋白测定正常。已发表的成人经验表明，这种疗法对年轻人睾丸转移性胚胎细胞癌的治疗非常有效，我们的病例报告将这种有利的经验扩展到儿童。毒性是巨大的，但考虑到与广泛转移性疾病相关的不良前景是合理的。总的来说，回顾的数据表明，这类治疗的进一步试验适用于儿童。
A child with widespread metastases successfully treated with chemotherapy alone is described. One course of combination chemotherapy using cis-platinum, vinblastine, and bleomycin produced disappearance of multiple pulmonary metastatic lesions. Four courses of therapy produced shrinkage and tumor sterilization of an abdominal mass. Twenty-six months after initiation of chemotherapy the patient is well, off of all therapy for fourteen months, and free of disease or drug related complication with normal creatinine clearance and alphafetoprotein determinations. The published adult experience demonstrates that this therapy is extremely effective for the treatment of metastatic embryonal cell carcinoma of the testis in young adults, and our case report extends this favorable experience into childhood. Toxicity is substantial, but justifiable considering the poor outlook associated with widespread metastatic disease. Collectively, the reviewed data suggest that further trials of this type of therapy are indicated in children.