Microstructure and compressive mechanical properties of cortical bone in children with osteogenesis imperfecta treated with bisphosphonates compared with healthy children
Microstructure and compressive mechanical properties of cortical bone in children with osteogenesis imperfecta treated with bisphosphonates compared with healthy children
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DOI：
10.1016/j.jmbbm.2014.12.020
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发表时间：
2015-06-01
影响因子：
3.9
通讯作者：
Hoc, Thierry
中科院分区：
文献类型：
--
作者：
Irnbert, Laurianne;Auregan, Jean-Charles;Hoc, Thierry
成骨不全症（Osteogenesis imperfecta， OI）是一种以骨组织质量改变为特征的遗传性疾病，但在宏观尺度上描述相关因素的数据很少。为了更好地了解微观结构改变对样品力学性能的影响，我们研究了六份经双膦酸盐治疗的成骨儿童皮质骨样品的结构和力学性能，并将其与三个对照组的性能进行了比较。使用扫描电子显微镜、高分辨率计算机断层扫描和压缩测试来评估这些特性。与对照组相比，在成骨不全中观察到更多的吸收腔和更高的骨细胞腔隙密度。此外，OI骨的孔隙率较高，宏观杨氏模量、屈服应力和极限应力均较低。成骨不全骨组织结构受损；较高的孔隙率和骨细胞腔隙密度对骨的力学性能产生负面影响，使骨更容易发生骨折。(C) 2015 Elsevier Ltd.版权所有。
Osteogenesis imperfecta (OI) is a genetic disorder characterized by a change in bone tissue quality, but little data are available to describe the factors involved at the macroscopic scale. To better understand the effect of microstructure alterations on the mechanical properties at the sample scale, we studied the structural and mechanical properties of six cortical bone samples from children with OI treated with bisphosphonates and compared them to the properties of three controls. Scanning electron microscopy, high resolution computed tomography and compression testing were used to assess these properties. More resorption cavities and a higher osteocyte lacunar density were observed in OI bone compared with controls. Moreover, a higher porosity was measured for OI bones along with lower macroscopic Young's modulus, yield stress and ultimate stress. The microstructure was impaired in OI bones; the higher porosity and osteocyte lacunar density negatively impacted the mechanical properties and made the bone more prone to fracture. (C) 2015 Elsevier Ltd. All rights reserved.