Neural Signaling in Cancer.

Neural Signaling in Cancer.
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DOI:
10.1146/annurev-neuro-111020-092702
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发表时间:
2022-07-08
影响因子:
13.9
通讯作者:
--
中科院分区:
医学1区
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--
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神经系统活动调节大脑和身体其他器官的发育、稳态和可塑性。这些机制在癌症中被破坏,以促进恶性生长。反过来,癌症调节神经结构和功能,以增加肿瘤微环境中的促生长神经信号。从神经科学的角度探讨癌症生物学将阐明目前致命形式的癌症的新治疗策略。在这篇综述中,我们强调了原发性脑肿瘤,脑转移瘤和实体瘤中调节癌症进展的神经信号传导机制。
Nervous system activity regulates development, homeostasis, and plasticity of the brain as well as other organs in the body. These mechanisms are subverted in cancer to propel malignant growth. In turn, cancers modulate neural structure and function to augment growth-promoting neural signaling in the tumor microenvironment. Approaching cancer biology from a neuroscience perspective will elucidate new therapeutic strategies for presently lethal forms of cancer. In this review, we highlight the neural signaling mechanisms recapitulated in primary brain tumors, brain metastases, and solid tumors throughout the body that regulate cancer progression.
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