Protein scaffolds in MAP kinase signalling.
Protein scaffolds in MAP kinase signalling.
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DOI：
10.1016/j.cellsig.2008.11.013
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发表时间：
2009-04
影响因子：
4.8
通讯作者：
Sacks DB
中科院分区：
文献类型：
--
作者：
Brown MD;Sacks DB
丝裂原活化蛋白激酶(MAPK)通路允许细胞解读外部信号并以适当的方式做出反应。不同的细胞功能，从分化和增殖到迁移和炎症，都受到MAPK信号的调节。因此，细胞已经发展出这样一种机制，通过这种单一的途径来调节来自广泛的激活因子的众多细胞反应。这种特异性是通过几种机制实现的，包括对MAPK信号成分的时间和空间控制。这种控制的关键是蛋白质支架，这是一种多结构域蛋白质，它与MAPK级联的组件相互作用，以组装信号复合体。在不同生物系统的不同支架上进行的研究表明，支架对MAPK信号转导起着重要的控制作用，影响信号强度、时间进程，更重要的是，影响细胞反应。因此，在基本的生理过程中，蛋白质支架是MAPK网络调节过程中不可或缺的元件。
The mitogen-activated protein kinase (MAPK) pathway allows cells to interpret external signals and respond in an appropriate way. Diverse cellular functions, ranging from differentiation and proliferation to migration and inflammation, are regulated by MAPK signalling. Therefore, cells have developed mechanisms by which this single pathway modulates numerous cellular responses from a wide range of activating factors. This specificity is achieved by several mechanisms, including temporal and spatial control of MAPK signalling components. Key to this control are protein scaffolds, which are multidomain proteins that interact with components of the MAPK cascade in order to assemble signalling complexes. Studies conducted on different scaffolds, in different biological systems, have shown that scaffolds exert substantial control over MAPK signalling, influencing the signal intensity, time course and, importantly, the cellular responses. Protein scaffolds, therefore, are integral elements in the modulation of the MAPK network in fundamental physiological processes.
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