Nanostructured injectable cell microcarriers for tissue regeneration.
Nanostructured injectable cell microcarriers for tissue regeneration.
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DOI：
10.2217/nnm-2016-0083
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发表时间：
2016-05
期刊：
影响因子：
5.5
通讯作者：
Zhanpeng Zhang;Thomas Eyster;P. Ma
中科院分区：
文献类型：
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作者：
Zhanpeng Zhang;Thomas Eyster;P. Ma
可生物降解聚合物微球因其可注射性、可生物降解性和药物掺入和释放能力而成为不规则形状组织缺损再生和修复的细胞载体。值得注意的是，纳米技术的最新进展允许在纳米尺度上操纵微球的物理和化学性质，创造纳米结构的微球，模仿天然细胞外基质的组成和/或结构。这些纳米结构微球，包括纳米复合微球和纳米纤维微球，已被用作组织再生的细胞载体。它们增强细胞的附着和增殖，促进细胞-载体的积极相互作用，促进干细胞分化，促进目标组织再生。本文综述了纳米微球作为可注射型、仿生型和细胞指导性细胞载体的研究进展。
Biodegradable polymer microspheres have emerged as cell carriers for the regeneration and repair of irregularly shaped tissue defects due to their injectability, controllable biodegradability and capacity for drug incorporation and release. Notably, recent advances in nanotechnology allowed the manipulation of the physical and chemical properties of the microspheres at the nanoscale, creating nanostructured microspheres mimicking the composition and/or structure of natural extracellular matrix. These nanostructured microspheres, including nanocomposite microspheres and nanofibrous microspheres, have been employed as cell carriers for tissue regeneration. They enhance cell attachment and proliferation, promote positive cell-carrier interactions and facilitate stem cell differentiation for target tissue regeneration. This review highlights the recent advances in nanostructured microspheres that are employed as injectable, biomimetic and cell-instructive cell carriers.