Cholesterol and ion channels.
Cholesterol and ion channels.
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DOI：
10.1007/978-90-481-8622-8_19
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发表时间：
2010
影响因子：
--
通讯作者：
Romanenko, Victor
中科院分区：
文献类型：
--
作者：
Levitan, Irena;Fang, Yun;Rosenhouse-Dantsker, Avia;Romanenko, Victor
各种离子通道，包括所有主要离子通道家族的成员，已被证明是由膜胆固醇水平的变化和分配到富含胆固醇的膜结构域的调节。一般来说，已经描述了几种类型的胆固醇效应。最常见的效应是通过膜胆固醇增加抑制通道活性，该效应描述于几种类型的内向整流K+通道、电压门控K+通道、Ca+2敏感性K+通道、电压门控Na+通道、N型电压门控Ca+2通道和体积调节阴离子通道。相反，几种类型的离子通道，如上皮阿米洛利敏感的Na+通道和瞬时受体电位通道，以及一些类型的内向整流和电压门控K+通道被证明是由胆固醇消耗抑制。胆固醇也被证明可以改变几个电压门控通道的动力学特性和电流-电压依赖性。最后，维持膜胆固醇水平是耦合离子通道信号级联所必需的。在机制方面，已经提出了三种一般机制：（i）胆固醇和通道蛋白之间的特异性相互作用，（ii）膜双层的物理性质的变化和（iii）维持蛋白质-蛋白质相互作用的支架。这篇综述的目的是系统地描述胆固醇在调节主要类型的离子通道中的作用，并在所提出的模型的背景下讨论这些影响。
A variety of ion channels, including members of all major ion channel families, have been shown to be regulated by changes in the level of membrane cholesterol and partition into cholesterol-rich membrane domains. In general, several types of cholesterol effects have been described. The most common effect is suppression of channel activity by an increase in membrane cholesterol, an effect that was described for several types of inwardly-rectifying K+ channels, voltage-gated K+ channels, Ca+2 sensitive K+ channels, voltage-gated Na+ channels, N-type voltage-gated Ca+2 channels and volume-regulated anion channels. In contrast, several types of ion channels, such as epithelial amiloride-sensitive Na+ channels and Transient Receptor Potential channels, as well as some of the types of inwardly-rectifying and voltage-gated K+ channels were shown to be inhibited by cholesterol depletion. Cholesterol was also shown to alter the kinetic properties and current-voltage dependence of several voltage-gated channels. Finally, maintaining membrane cholesterol level is required for coupling ion channels to signalling cascades. In terms of the mechanisms, three general mechanisms have been proposed: (i) specific interactions between cholesterol and the channel protein, (ii) changes in the physical properties of the membrane bilayer and (iii) maintaining the scaffolds for protein-protein interactions. The goal of this review is to describe systematically the role of cholesterol in regulation of the major types of ion channels and to discuss these effects in the context of the models proposed.
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影响因子：
3.3
作者：
Bowles, DK;Heaps, CL;Price, EM
通讯作者：
Price, EM
DOI：
10.1111/j.1749-6632.1999.tb11298.x
发表时间：
1999-01-01
期刊：
MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS
影响因子：
--
作者：
Bond, CT;Maylie, J;Adelman, JP
通讯作者：
Adelman, JP
影响因子：
20.1
作者：
Bergdahl, A;Gomez, MF;Swärd, K
通讯作者：
Swärd, K
影响因子：
5.5
作者：
Balut, C;Steels, P;Jans, D
通讯作者：
Jans, D
影响因子：
6.7
作者：
Brownlow, SL;Sage, SO
通讯作者：
Sage, SO