A facile approach for the synthesis of nido-carborane fused oxazoles via one pot deboronation/cyclization of 9-amide-o-carboranes
A facile approach for the synthesis of nido-carborane fused oxazoles via one pot deboronation/cyclization of 9-amide-o-carboranes
复制标题
一种通过 9-酰胺-邻碳硼烷一锅脱硼/环化合成硝基碳硼烷稠合恶唑的简便方法
DOI：
10.1039/c8cc07728b
复制
发表时间：
2019
影响因子：
4.9
通讯作者：
Yang Junxiao
中科院分区：
文献类型：
--
作者：
Zhang Cai Yan;Cao Ke;Xu Tao Tao;Wu Ji;Jiang Linhai;Yang Junxiao
以9-酰胺基-O-碳硼烷为原料，在Pd（OAc）2、AgOAc和K2 CO 3的协同作用下，一锅脱硼/环化反应合成了巢式-7，8-碳硼烷并恶唑。基于关键脱硼中间体的成功分离和结构表征，提出了一个合理的机制，包括酰胺导向的B-H键亲电钯化和脱硼/环化过程。
A one pot deboronation/cyclization of 9-amide-o-carboranes for the synthesis of nido-7,8-carborane fused oxazole by cooperation of Pd(OAc)2, AgOAc and K2CO3 has been developed. A plausible mechanism involving an amide directed electrophilic palladation of the B–H bond and deboronation/cyclization process was proposed based on the successful isolation and structural characterization of the key deboronated intermediate.