Brain and retinal damage from lathyrus excitotoxin, β-N-oxalyl-L-α,β-diaminopropionic acid
Brain and retinal damage from lathyrus excitotoxin, β-N-oxalyl-L-α,β-diaminopropionic acid
复制标题
山黧豆兴奋毒素、β-N-草酰-L-α,β-二氨基丙酸对大脑和视网膜造成的损害
作者：
J. Olney;C. H. Misra;V. Rhee
长期以来，在世界某些地区，特别是在饥荒时期，人类食用红豆与神经红豆症的爆发有关，这是一种以痉挛性截瘫为特征的致残性神经紊乱。一种神经兴奋性氨基酸，β- n -草酰- l -α，β-二氨基丙酸（ODAP），被怀疑是从土草种子中分离出来的神经毒性原理。尽管有报道称成年猴子在腰椎鞘内注射ODAP4后出现下肢瘫痪，并且在新生雏鸡中通过腹腔注射引起了类似的症状，但缺乏证据表明全身注射ODAP会损伤中枢神经组织。我们现在报告说，ODAP，腹腔注射到未成熟的小鼠，诱导病变视网膜，下丘脑和下髓质。这种损伤模式与口服或皮下注射谷氨酸（Glu）后在动物中所显示的相似。
HUMAN consumption of lathyrus peas, especially during periods of famine, has long been associated in certain parts of the world with outbreaks of neurolathyrism, a crippling neurological disorder characterised by spastic paraplegia1. A neuroexcitatory2 amino acid, β-N-oxalyl-L-α,β-diaminopropionic acid (ODAP), isolated from the seeds of Lathyrus sativus3 is suspected to be the responsible neurotoxic principle. Although paralysis of the lower extremities has been reported in adult monkeys after lumbar intrathecal administration of ODAP4, and similar symptoms have been induced in newborn chicks by intraperitoneal administration3, evidence for central nervous tissue damage from systemically administered ODAP has been lacking. We now report that ODAP, administered intraperitoneally to immature mice, induces lesions in the retina, hypothalamus and lower medulla. This pattern of damage is similar to that demonstrated in animals after oral or subcutaneous administration of glutamate (Glu).