What is oxidative stress?
What is oxidative stress?
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DOI：
10.1016/s0026-0495(00)80077-3
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发表时间：
2000-02-01
影响因子：
9.8
通讯作者：
Betteridge, DJ
中科院分区：
文献类型：
--
作者：
Betteridge, DJ
氧化应激，定义为活性氧产生之间的平衡紊乱（自由基）和抗氧化防御，讨论了其在糖尿病组织损伤的产生中可能发挥的作用，描述了重要的自由基，讨论了其生物来源，以及主要的抗氧化防御机制，自由基损伤的可能后果的例子提供了特别强调脂质过氧化作用。最后，是否氧化应激增加糖尿病的问题进行了讨论。Copyright（C）2000 by W.B.桑德斯公司
Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses, is discussed in relation to its possible role in the production of tissue damage in diabetes mellitus, Important free radicals are described and biological sources of origin discussed, together with the major antioxidant defense mechanisms, Examples of the possible consequences of free radical damage are provided with special emphasis on lipid peroxidation. Finally, the question of whether oxidative stress is increased in diabetes mellitus is discussed. Copyright (C) 2000 by W.B. Saunders Company.