Correlation between intrahepatic hepatitis B virus cccDNA levels and other activity markers in patients with HBeAg-negative chronic hepatitis B infection
Correlation between intrahepatic hepatitis B virus cccDNA levels and other activity markers in patients with HBeAg-negative chronic hepatitis B infection
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DOI：
10.1097/meg.0b013e32834ba13a
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发表时间：
2011-11-01
影响因子：
2.1
通讯作者：
Tasyaran, Mehmet A.
中科院分区：
文献类型：
--
作者：
Guner, Rahmet;Karahocagil, Mustafa;Tasyaran, Mehmet A.
目的本研究的目的是阐明肝内（IH）乙型肝炎病毒（HBV）共价闭合环状DNA（cccDNA）水平与其他HBV复制中间体和肝细胞HBV抗原表达之间的关系。 患者和方法乙型肝炎表面抗原（HBsAg）阳性、乙型肝炎早期抗原阴性、血清HBV DNA水平10（4）拷贝/ml或更高以及持续或间歇性丙氨酸氨基转移酶水平升高的患者结果 纳入 59 名患者。 IH HBV cccDNA 水平与血清 HBV DNA 水平具有良好的相关性（P
Objective The aim of this study was to demonstrate the relation between intrahepatic (IH) hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) levels and the other HBV replicative intermediates and hepatocyte expression of HBV antigens.Patients and methods Patients with hepatitis B surface antigen (HBsAg) positivity, hepatitis B early antigen negativity, serum HBV DNA levels 10(4) copies/ml or more, and constantly or intermittently increased alanine aminotransferase levels were included.Results Fifty-nine patients were included. There was a good correlation between the levels of IH HBV cccDNA and serum HBV DNA (P