Impairment in recognition of emotional facial expressions in Alzheimer's disease is represented by EEG theta and alpha responses
Impairment in recognition of emotional facial expressions in Alzheimer's disease is represented by EEG theta and alpha responses
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DOI：
10.1111/psyp.13434
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发表时间：
2019-07-02
期刊：
影响因子：
3.7
通讯作者：
Yener, Gorsev G.
中科院分区：
文献类型：
--
作者：
Guntekin, Bahar;Hanoglu, Lutfu;Yener, Gorsev G.
行为学研究表明，阿尔茨海默病（AD）患者的面部表情识别可能受损。面部表情的识别和再认可以由事件相关的脑振荡来表示。本研究旨在分析AD患者的脑电事件相关振荡，并确定面部表情识别受损的电生理指标。记录30名健康对照者和30名AD患者在感知三种不同面部表情（愤怒、高兴、中性）时的EEG。使用EEGLAB开放工具箱在theta（4 - 7）和alpha（8 - 13 Hz）频带中分析事件相关功率谱和锁相。θ功率谱存在显著的面部表情x组交互作用（p <0.05）;健康对照组在感知愤怒面部表情期间的θ功率高于AD组（p <0.05）。两组之间存在显著的半球差异（p <0.05）。在健康受试者中，右半球α功率占主导地位。然而，AD患者没有这种α功率不对称。本研究首次在文献中，提出了AD患者面部表情识别受损的电生理指标。目前的研究可能是未来研究的基础，将分析不同类型的痴呆症患者的情绪处理，这项研究可能提供了在临床实践中观察到的行为问题的电生理相关指标。
Behavioral studies have shown that the recognition of facial expressions may be impaired in patients with Alzheimer's disease (AD). The identification and recognition of a facial expression might be represented by event-related brain oscillations. The present study aims to analyze EEG event-related oscillations and determine the electrophysiological indicators of impaired facial expression recognition in AD patients. EEGs of 30 healthy controls and 30 AD patients were recorded during their perception of three different facial expressions (angry, happy, neutral). Event-related power spectrum and phase locking were analyzed in the theta (4-7) and alpha (8-13 Hz) frequency bands with the EEGLAB open toolbox. There was a significant facial Expression x Group interaction (p < 0.05) for the theta power spectrum; the healthy control group had higher theta power than the AD group during the perception of angry facial expressions (p < 0.05). There was a significant hemisphere difference between the two groups (p < 0.05). There was a right hemisphere alpha power dominance in healthy subjects. However, AD patients did not have this alpha power asymmetry. The present study, for the first time in the literature, presents the electrophysiological indicators of impaired recognition of facial expression in AD patients. The current study could be a basis for future studies that will analyze emotional processing in different kinds of dementia patients, and this study may have provided indicators of electrophysiological correlates of behavioral problems observed in clinical practice.