Immunological Classification of Acute Lymphoblastic Leukaemias: Evaluation of its Clinical Significance in a Hundred Patients
Immunological Classification of Acute Lymphoblastic Leukaemias: Evaluation of its Clinical Significance in a Hundred Patients
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急性淋巴细胞白血病的免疫学分类：一百名患者的临床意义评估
DOI：
10.1111/j.1365-2141.1976.tb03547.x
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发表时间：
1976
影响因子：
6.5
通讯作者：
M. Seligmann
中科院分区：
文献类型：
--
作者：
J. Brouet;F. Valensi;M. Daniel;G. Flandrin;J. Preud’homme;M. Seligmann
Summary. The use of T and B lymphocyte markers and of different antisera raised against malignant B cells and fetal thymocytes allowed the classification of 100 patients with acute lymphoblastic leukaemia (ALL) into three groups. (1) Patients with non‐T non‐B ALL whose cells were devoid of conventional B and T markers but characterized by a leukaemia associated antigen (69 cases). (2) Patients with T‐derived ALL (28 cases). (3) Patients with ALL of B cell origin (three cases). The search for haematological and clinical correlations showed that those patients with T‐derived ALL tended to have a higher leucocyte count (P= 0.05) and acid phosphatase positivity of blast cells (P= 0.01), a higher incidence of tumour presentation (P= 0.05) and a thymic mass. Survival curves for the two main groups of patients are similar at 36 months but meningeal relapses were more frequent in patients with T‐derived ALL (P= 0.02).
