Cadherin subclasses: differential expression and their roles in neural morphogenesis.
Cadherin subclasses: differential expression and their roles in neural morphogenesis.
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钙粘蛋白亚类：差异表达及其在神经形态发生中的作用。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
A. Nagafuchi
中科院分区：
文献类型：
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作者：
M. Takeichi;Hiroyuki Inuzuka;K. Shimamura;Toshihiko Fujimori;A. Nagafuchi
钙粘蛋白同型结合细胞。因此，表达相同钙粘蛋白的细胞选择性地相互粘附，并且它们不会在体外与表达其他类型钙粘蛋白的细胞随机混合。神经组织表达多种类型的钙粘蛋白，每种钙粘蛋白的表达在组织发育过程中受到时空调节。因此，这个分子家族可以对神经系统中不同类型的细胞进行分类。N-cadherin表达的调控对神经管的早期发育也很重要。注射mRNA诱导非洲爪蟾胚胎异位表达N-cadherin，导致神经管结构紊乱或与表皮融合。这些结果表明，在定量和定性水平上精确调节钙粘蛋白的表达对神经形态发生至关重要。
Cadherins homophilically bind cells. Thus, cells expressing identical cadherins adhere selectively to each other, and they do not randomly intermix with the cells expressing other types of cadherins in vitro. Neural tissues express multiple types of cadherins, and the expression of each cadherin type is spatiotemporally regulated within a tissue during development. This molecular family therefore could operate for the sorting of different cell types in the nervous system. The regulation of N-cadherin expression is also important for the early development of the neural tube. The ectopic expression of N-cadherin in Xenopus embryos, which was induced by mRNA injection, led to the disorganization of neural tube structures or the fusion of the neural tube to the epidermis. These results suggest that the precise regulation of cadherin expression at the quantitative as well as at the qualitative level si crucial for neural morphogenesis.