Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain
Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain
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DOI：
10.1016/j.plefa.2014.01.005
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发表时间：
2015-01-01
影响因子：
3
通讯作者：
Guichardant, M.
中科院分区：
文献类型：
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作者：
Lagarde, M.;Hachem, M.;Guichardant, M.
1-乙酰基，2-二十二碳六烯酰基-甘油磷酸胆碱（AceDoPC）已被制成，以防止二十二碳六烯酰基（DHA）迅速移动到cn -1的位置，当它存在于1- lysso，2-二十二碳六烯酰基- gpc （lysoPC-DHA）时，一个有效的DHA转运体到大脑。当与人血液孵育时，AceDoPC在与血浆白蛋白和脂蛋白结合以及DHA并入血小板和红细胞方面的表现比PC-DHA更接近lysoPC-DHA。此外，与未酯化DHA相比，AceDoPC能更有效地预防实验性脑卒中的有害影响。此外，AceDoPC抑制血小板活化因子诱导的人血小板聚集。总的来说，AceDoPC可能作为一种有效的DHA转运体进入大脑，并作为一种神经保护剂。(C) 2014 Elsevier Ltd.版权所有。
1-acetyl,2-docosahexaenoyl-glycerophosphocholine (AceDoPC) has been made to prevent docosahexaenoyl (DHA) to move to the sn-1 position as it rapidly does when present in 1-lyso,2-docosahexaenoyl-GPC (lysoPC-DHA), an efficient DHA transporter to the brain. When incubated with human blood, AceDoPC behaves closer to lysoPC-DHA than PC-DHA in terms of binding to plasma albumin and lipoproteins, and DHA incorporation into platelets and red cells. In addition, AceDoPC prevents more efficiently the deleterious effects of the experimental stroke in rats than does unesterified DHA. Also, AceDoPC inhibits platelet-activating factor-induced human blood platelet aggregation. Overall, AceDoPC might act as an efficient DHA transporter to the brain, and as a neuro-protective agent by itself. (C) 2014 Elsevier Ltd. All rights reserved.