EXACERBATION OF LYME ARTHRITIS IN BEIGE MICE
EXACERBATION OF LYME ARTHRITIS IN BEIGE MICE
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DOI：
10.1093/infdis/172.3.778
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发表时间：
1995-09-01
影响因子：
6.4
通讯作者：
DESOUZA, M
中科院分区：
文献类型：
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作者：
BARTHOLD, SW;DESOUZA, M
在具有和不具有米色（bg）突变的疾病抗性C57/BL 6（B6）和易感性C3 H/He（C3 H）小鼠中探索伯氏疏螺旋体诱导的疾病易感性，所述米色（bg）突变与粒细胞和NK细胞功能障碍相关。B6和C3 H小鼠的关节炎发病率和严重程度均高于同类小鼠，B6-bg小鼠的关节炎严重程度与C3 H小鼠相同。在B6-bg小鼠的关节组织中观察到螺旋体，但在B6小鼠中未观察到。从组织中分离出的螺旋体或对B的免疫球蛋白滴度无差异。在组间观察到burgdorferi。在B6和C3 H小鼠中，用环磷酰胺消耗粒细胞和用二氧化硅消耗巨噬细胞改变了关节炎的易感性，但在B6小鼠中通过血清疗法消耗NK细胞对疾病没有影响。这项研究表明，小鼠对莱姆关节炎的先天遗传抗性可以通过单个基因突变来克服，这可能是通过粒细胞功能介导的。
Borrelia burgdorferi-induced disease susceptibility was explored in disease-resistant C57/BL6 (B6) and -susceptible C3H/He (C3H) mice with and without the beige (bg) mutation, which is associated with granulocyte and NK cell dysfunction. Both B6 and C3H mice had more prevalent and severe arthritis than their congenic partners, and B6-bg mice developed arthritis equal in severity to that in C3H mice. Spirochetes were visualized in joint tissue of B6-bg mice but not B6 mice. No differences in spirochete isolation from tissues or immunoglobulin titers to B. burgdorferi were noted between groups. Depletion of granulocytes with cyclophosphamide and macrophages with silica in B6 and C3H mice modified arthritis susceptibility, but depletion of NK cells by serotherapy in B6 mice had no effect on disease. This study demonstrates that innate genetic resistance to Lyme arthritis in mice can be overcome by a single gene mutation, which is probably mediated through granulocyte function.