Failure of Demonstrated Clinical Efficacy of Antibiotic-Bonded Continuous Ambulatory Peritoneal Dialysis (CAPD) Catheters
Failure of Demonstrated Clinical Efficacy of Antibiotic-Bonded Continuous Ambulatory Peritoneal Dialysis (CAPD) Catheters
复制标题
抗生素粘合连续非卧床腹膜透析 (CAPD) 导管的临床疗效未得到证实
DOI：
10.1177/089686089001000115
复制
发表时间：
1990
影响因子：
2.8
通讯作者：
R. Greco
中科院分区：
文献类型：
--
作者：
S. Trooskin;R. Harvey;T. Lennard;R. Greco
以往的体外、体内和初步临床报告都证明了将抗生素非共价结合到持续非卧床腹膜透析(CAPO)导管表面在减少感染并发症方面的效果。完成了一项更大规模的前瞻性随机临床试验。86名慢性肾功能衰竭患者参加了这项研究，并随机接受表面活性物质治疗的对照导管和未治疗的对照导管。所有导管在插入时均浸泡在头孢西丁中。两组在既往疾病、年龄和性别方面具有可比性。两组导管感染、腹膜炎、机械并发症的发生率无差异。微生物培养结果也没有差异。因此，我们得出的结论是，这项临床试验并没有证明通过抗生素粘合可以减少导管相关的感染并发症。
Previous in vitro, in vivo, and a preliminary clinical report have demonstrated efficacy of noncovalently bonding antibiotics to the surface of continuous ambulatory peritoneal dialysis (CAPO) catheters in decreasing infectious complications. A larger prospective randomized clinical trial was completed. Eighty-six patients with chronic renal failure were enrolled in the study and randomized to receive either a surfactant treated or untreated control catheter. All catheters were soaked in cefoxitin at the time of insertion. Groups were comparable in terms of pre-existing illnesses, age, and gender. No differences were shown in the incidence of cathetertract infections, peritonitis or mechanical complications. There was also no differences in microbiologic culture results. Therefore, it is concluded that this clinical trial did not demonstrate a reduction in catheter-related infectious complications by antibiotic bonding.