Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients.
Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients.
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DOI：
10.12659/msm.908406
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发表时间：
2018-08-03
期刊：
影响因子：
--
通讯作者：
Zhu P
中科院分区：
文献类型：
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作者：
Zhao P;Miao J;Zhang K;Lv M;Han Q;Zhu P
系统性红斑狼疮（SLE）患者，尤其是狼疮肾炎（LN）患者在病程中会经历血管损伤和修复。由于最近发现的血管生成T细胞（angiogenic T cells, Tang）与内皮祖细胞（endothelial progenitor cells, EPCs）共同参与内皮修复，本研究探讨了LN患者循环中的Tang细胞及其与疾病特征的潜在相关性。采用流式细胞术检测67例SLE患者外周血循环Tang细胞和EPCs；其中32例LN， 30例健康对照（hc）。免疫法测定血浆白细胞介素IL-17、IL-8、血管内皮生长因子（VEGF）水平。LN患者与非LN患者和hcc患者相比，循环Tang细胞的百分比明显增加，且与EPC、VEGF水平呈正相关。此外，循环Tang细胞百分比与LN患者蛋白尿程度呈正相关。LN患者循环Tang细胞水平的升高可能在这些患者内皮功能障碍的平衡中起作用。
Patients with systemic lupus erythematosus (SLE), especially with lupus nephritis (LN), undergo vascular damage and repair during the course of the disease. Since the recently identified angiogenic T cells (Tang) are involved in endothelial repair coupled with endothelial progenitor cells (EPCs), this study investigated the circulating Tang cells in LN patients and their potential correlations with disease features. Circulating Tang cells and EPCs were assessed by flow cytometry in peripheral blood samples from 67 SLE patients; of these, 32 had LN and 30 were matched healthy controls (HCs). The plasma levels of interleukin IL-17, IL-8, and vascular endothelial growth factor (VEGF) were quantified by immunoassays. The percentage of circulating Tang cells in LN patients was significantly increased as compared to the non-LN patients and HCs, and they were positively correlated with the level of EPC and VEGF. Additionally, circulating Tang cell percentages were positively correlated with the extent of proteinuria in LN patients. The increased levels of circulating Tang cells in LN patients might play a role in the balance of endothelium dysfunction in these patients.