ASPIRIN AND NONSTEROIDAL ANTIINFLAMMATORY DRUG-USE AND THE RISK OF SUBSEQUENT COLORECTAL-CANCER
ASPIRIN AND NONSTEROIDAL ANTIINFLAMMATORY DRUG-USE AND THE RISK OF SUBSEQUENT COLORECTAL-CANCER
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DOI：
10.1001/archinte.154.4.394
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发表时间：
1994-02-28
影响因子：
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通讯作者：
WILCOX, CM
中科院分区：
文献类型：
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作者：
PELEG, II;MAIBACH, HT;WILCOX, CM
目的：为了验证这一假设，即经常使用阿司匹林和其他非甾体抗炎药（NSAID）与随后的结直肠癌风险呈负相关。设计：病例对照研究，每个结直肠癌病例有4名年龄和性别匹配的对照受试者。人群和设置：佐治亚州亚特兰大市一家大型市立教学医院的患者人群。主要结果指标：在结肠直肠癌诊断前4年内，结肠直肠癌的发病率作为阿司匹林、非阿司匹林NSAID和对乙酰氨基酚的函数，主要结果：结肠直肠癌的发病风险由比值比估计，随着暴露于阿司匹林的天数增加，结肠直肠癌的发病风险呈剂量依赖性线性下降（似然比统计：累计天数，P
Objective: To test the hypothesis that the regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is negatively associated with the risk of subsequent colorectal cancer.Design: Case-control study with four age- and sex-matched control subjects for each incident colorectal cancer case.Population and Setting: Patient population of a large municipal teaching hospital in Atlanta, Ga.Main Outcome Measure: Odds of colorectal cancer as a function of aspirin, nonaspirin NSAIDs, and acetaminophen dispensed to the study population in the 4 years prior to incident colorectal cancer diagnosis.Main Results: The risk of colorectal cancer estimated by odds ratios decreased with inceasing days of exposure to aspirin linearly in a dose-dependent fashion (likelihood ratio statistic: for cumulative days, P