Receptors for Human Luteinizing Hormone in Human Corpora Luteal Tissue
Receptors for Human Luteinizing Hormone in Human Corpora Luteal Tissue
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人类黄体组织中人类黄体生成激素的受体
DOI：
10.1210/jcem-36-1-148
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
R. Ryan
中科院分区：
文献类型：
--
作者：
C. Y. Lee;C. Coulam;N. Jiang;R. Ryan
在人黄体组织中发现hLH特异性受体。125 I-hLH的结合是一个时间依赖性的饱和过程，可被未标记的人LH竞争性抑制。使用人黄体组织，发现受体-LH相互作用的解离常数为1.1 × 10− 9 M，这与使用大鼠黄体组织发现的解离常数相当一致。LH结合位点的浓度在从10个不同受试者获得的黄体中显示出相当大的变异性。
Receptors, specific for hLH, were found in human luteal tissue. Binding of 125I-hLH was a time-dependent, saturable process that could be competitively inhibited by unlabeled human LH. The dissociate constant of the receptor-LH interaction, using human luteal tissue, was found to be 1.1 × 10−9M, which is in reasonable agreement with the dissociation constant found using rat luteal tissue. The concentration of LH binding site showed considerable variability among corpora lutea obtained from ten different subjects.