Prognostic value of DNA ploidy status in patients with oral leukoplakia
Prognostic value of DNA ploidy status in patients with oral leukoplakia
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DOI：
10.1016/j.oraloncology.2011.07.025
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发表时间：
2011-10-01
期刊：
影响因子：
4.8
通讯作者：
Braakhuis, Boudewijn J. M.
中科院分区：
文献类型：
--
作者：
Bremmer, Jantine F.;Brakenhoff, Ruud H.;Braakhuis, Boudewijn J. M.
口腔白斑病是一种潜在的恶性疾病，估计每年有1-2%的人会发展成口腔癌。为探讨DNA倍体对口腔白斑恶性进展的预测价值，对62例口腔白斑患者进行了组织病理学和DNA图像分析。考克斯回归分析建立无进展生存期与DNA倍体状态之间的关系。在随访时间（中位数69个月）中，13例患者发展为口腔鳞状细胞癌（OSCC）。在27例（44%）患者中观察到DNA非整倍体，并与较短的无进展生存期显著相关[风险比为3.7，95%置信区间（CI）为1.1和13.0，p值为0.04]。敏感性和特异性评分分别为54%和60%。非整倍体与异型增生分级无关（卡方分析）。口腔白斑中DNA非整倍体与OSCC进展风险增加相关。然而，对于个体白斑患者，DNA倍体状态作为单一生物标志物对预测癌症进展的价值有限。(C)2011年由Elsevier Ltd.出版
Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia.A cohort of 62 leukoplakia patients was studied and their biopsy was examined with standard histopathology and DNA image cytometry. Cox regression analysis was performed to establish the relationship between progression-free survival and the DNA ploidy status.During the follow-up time (median of 69 months) 13 patients developed an oral squamous cell carcinoma (OSCC). DNA aneuploidy was observed in 27 (44%) patients and was significantly associated with a shorter progression-free survival [Hazard ratio of 3.7, 95% confidence intervals (CI) of 1.1 and 13.0 and a p-value of 0.04]. Sensitivity and specificity scores were 54% and 60%, respectively. Aneuploidy was not correlated with dysplasia grading (chi-square analysis).DNA aneuploidy in oral leukoplakia is associated with an increased risk of progression to OSCC. However, for the individual leukoplakia patient, DNA ploidy status as single biomarker has limited value to predict progression to cancer. (C) 2011 Published by Elsevier Ltd.