Making Security Viral: Shifting Engineering Biology Culture and Publishing
Making Security Viral: Shifting Engineering Biology Culture and Publishing
复制标题
让安全病毒式传播：改变工程生物学文化和出版
DOI：
10.1021/acssynbio.1c00324
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发表时间：
2022
影响因子：
4.7
通讯作者：
Isaacs, Farren J.
中科院分区：
文献类型：
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作者：
Mackelprang, Rebecca;Adamala, Katarzyna P.;Aurand, Emily R.;Diggans, James C.;Ellington, Andrew D.;Evans, Samuel Weiss;Fortman, J. L.;Hillson, Nathan J.;Hinman, Albert W.;Isaacs, Farren J.
大规模、快速构建、合成和编辑基因和基因组的能力，与工程生物学的其他工具协同作用，能够实现对社会产生深远影响的突破性应用。随着 2020 年初春 SARS-CoV-2 在世界各地传播，研究人员迅速动员起来，利用这些工具开发 COVID-19 的诊断、治疗和疫苗。知识共享对于快速进步至关重要。一些出版物描述了在实验室中使用反向遗传学从头构建 SARS-CoV-2，其中一种以协议的形式进行。考虑到该病毒造成的明显危害、缓解疫苗和治疗方法的分配不均、其对变异体的未知功效，以及不习惯处理高传染性大流行病原体的实验室对这项研究的兴趣，此类出版物（尤其是作为方案）存在风险。我们描述了注意事项并提供了增强合成生物学研究和技术出版安全性的建议。我们建议：（1）对某些致病病毒的从头合成方案手稿进行强制性安全和安保审查； (2) 如果发表，此类论文在正文中包含有关安全考虑因素的讨论或审查过程的描述； (3) 制定一个治理框架，在工程生物学/合成生物学稿件的出版过程中纳入基本的安全审查，以建立和支持一个安全可靠的研究企业，能够最大限度地发挥其积极影响并最大限度地减少任何负面结果。
The ability to construct, synthesize, and edit genes and genomes at scale and with speed enables, in synergy with other tools of engineering biology, breakthrough applications with far-reaching implications for society. As SARS-CoV-2 spread around the world in early spring of 2020, researchers rapidly mobilized, using these tools in the development of diagnostics, therapeutics, and vaccines for COVID-19. The sharing of knowledge was crucial to making rapid progress. Several publications described the use of reverse genetics for thede novoconstruction of SARS-CoV-2 in the laboratory, one in the form of a protocol. Given the demonstrable harm caused by the virus, the unequal distribution of mitigating vaccines and therapeutics, their unknown efficacy against variants, and the interest in this research by laboratories unaccustomed to working with highly transmissible pandemic pathogens, there are risks associated with such publications, particularly as protocols. We describe considerations and offer suggestions for enhancing security in the publication of synthetic biology research and techniques. We recommend: (1) that protocol manuscripts for thede novosynthesis of certain pathogenic viruses undergo a mandatory safety and security review; (2) that if published, such papers include descriptions of the discussions or review processes that occurred regarding security considerations in the main text; and (3) the development of a governance framework for the inclusion of basic security screening during the publication process of engineering biology/synthetic biology manuscripts to build and support a safe and secure research enterprise that is able to maximize its positive impacts and minimize any negative outcomes.