Sphingosine-1-phosphate synthesis and functions in mast cells.
Sphingosine-1-phosphate synthesis and functions in mast cells.
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DOI：
10.2217/17460875.3.6.665
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发表时间：
2008-12-01
期刊：
影响因子：
--
通讯作者：
Spiegel S
中科院分区：
文献类型：
--
作者：
Price MM;Oskeritzian CA;Milstien S;Spiegel S
鞘脂不仅是所有真核细胞膜的主要脂质组分，而且它们还包括调节各种生物反应的生物活性信号分子的重要家族。鞘脂代谢物鞘氨醇-1-磷酸（S1 P）是免疫反应的关键调节剂。S1 P的细胞水平由其合成（涉及两种鞘氨醇激酶（SphK 1和SphK 2））与其降解（涉及S1 P裂解酶和S1 P磷酸酶）之间的平衡决定。S1 P主要通过其细胞表面受体进行信号传导，也可能具有细胞内功能。S1 P在肥大细胞中具有重要的功能，肥大细胞是过敏反应的主要效应器。肥大细胞上IgE受体的抗原触发激活两种SphK，导致S1 P的产生，S1 P被释放并调节和放大肥大细胞功能，包括脱粒以及细胞因子和趋化因子释放。
Sphingolipids are not only major lipid components of all eukaryotic cell membranes, but they also comprise an important family of bioactive signaling molecules that regulate a diverse array of biological responses. The sphingolipid metabolite sphingosine-1-phosphate (S1P), is a key regulator of immune responses. Cellular levels of S1P are determined by the balance between its synthesis, involving two sphingosine kinases (SphK1 and SphK2), and its degradation, involving S1P lyase and S1P phosphatases. S1P mainly signals through its cell-surface receptors and may also have intracellular functions. S1P has important functions in mast cells – the major effectors of allergic responses. Antigen triggering of IgE receptors on mast cells activates both SphKs resulting in the production of S1P that is released and regulates and amplifies mast cell functions, including degranulation as well as cytokine and chemokine release.
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