Exercise Prevention of Cardiovascular Disease in Breast Cancer Survivors.
Exercise Prevention of Cardiovascular Disease in Breast Cancer Survivors.
复制标题
DOI：
10.1155/2015/917606
复制
发表时间：
2015
影响因子：
--
通讯作者：
Davis MK
中科院分区：
文献类型：
--
作者：
Kirkham AA;Davis MK
由于越来越有效的治疗，乳腺癌死亡率在过去几十年中显著下降。随着被诊断患有乳腺癌的妇女的预期寿命增加，人们认识到，这些妇女患心血管疾病的风险增加，部分原因是治疗的心脏毒性副作用。本文综述了运动在预防乳腺癌化疗相关的心血管毒性和改善乳腺癌幸存者心血管危险因素方面的作用的证据。越来越多的证据表明，这种保护作用的主要机制似乎是改善心脏和血管系统的抗氧化能力，随后减少这些结构中与治疗相关的氧化应激。需要进一步的临床研究来确定运动是否是一种可行且有效的非药物治疗，以降低乳腺癌幸存者的心血管发病率和死亡率，以确定其有效的癌症治疗方法，并确定最佳运动剂量。需要对心血管功能变化敏感的安全和非侵入性措施来回答患者人群中的这些问题。心脏应变、内皮功能和心脏生物标志物是该领域临床研究的建议结局指标。
Thanks to increasingly effective treatment, breast cancer mortality rates have significantly declined over the past few decades. Following the increase in life expectancy of women diagnosed with breast cancer, it has been recognized that these women are at an elevated risk for cardiovascular disease due in part to the cardiotoxic side effects of treatment. This paper reviews evidence for the role of exercise in prevention of cardiovascular toxicity associated with chemotherapy used in breast cancer, and in modifying cardiovascular risk factors in breast cancer survivors. There is growing evidence indicating that the primary mechanism for this protective effect appears to be improved antioxidant capacity in the heart and vasculature and subsequent reduction of treatment-related oxidative stress in these structures. Further clinical research is needed to determine whether exercise is a feasible and effective nonpharmacological treatment to reduce cardiovascular morbidity and mortality in breast cancer survivors, to identify the cancer therapies for which it is effective, and to determine the optimal exercise dose. Safe and noninvasive measures that are sensitive to changes in cardiovascular function are required to answer these questions in patient populations. Cardiac strain, endothelial function, and cardiac biomarkers are suggested outcome measures for clinical research in this field.