Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients
Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients
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DOI：
10.1016/j.amjsurg.2012.03.012
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发表时间：
2012-12-01
影响因子：
3
通讯作者：
Milfeld, Douglas J.
中科院分区：
文献类型：
--
作者：
Bjordahl, Paul M.;Helmer, Stephen D.;Milfeld, Douglas J.
背景：大约 25% 至 45% 的冠状动脉搭桥术 (CABG) 手术后发生心房颤动。氧化应激和相关的电生理重塑被认为是这种心房颤动的潜在原因。围手术期补充抗氧化剂抗坏血酸已被评估为预防剂。目前的研究旨在评估抗坏血酸在减少 CABG 患者心房颤动方面的功效。方法：在非急诊 CABG 患者中进行了一项前瞻性、随机、安慰剂对照、三盲、单机构研究。监测受试者的心律失常发作和其他并发症。结果：89 名治疗受试者和 96 名对照受试者完成了研究方案。各组之间的人口统计学、合并症和术前药物相似。手术特点和术后药物使用也相似。治疗组心房颤动的发生率为 30.3%，对照组为 30.2% (P = .985)。术后并发症或死亡率没有差异。结论：我们的数据表明，除了常规术后护理之外补充抗坏血酸并不能减少冠状动脉旁路移植术后的心房颤动。 (C) 2012 Elsevier Inc. 保留所有权利。
BACKGROUND: Atrial fibrillation occurs after approximately 25% to 45% of coronary artery bypass graft (CABG) surgeries. Oxidative stress and related electrophysiological remodeling has been proposed as a potential cause of this atrial fibrillation. Perioperative supplementation of the antioxidant ascorbic acid has been evaluated as a preventive agent. The current investigation was conducted to evaluate the efficacy of ascorbic acid in reducing atrial fibrillation in CABG patients.METHODS: A prospective, randomized, placebo-controlled, triple-blind, single-institution study was conducted in nonemergency CABG patients. Subjects were monitored for episodes of arrhythmia and other complications.RESULTS: Eighty-nine treatment and 96 control subjects completed the study protocol. Demographics, comorbidities, and preoperative drugs were similar between groups. Surgical characteristics and postoperative medication use also were similar. The incidence of atrial fibrillation was 30.3% in the treatment group and 30.2% in the control group (P = .985). No difference was found in postoperative complications or mortality.CONCLUSIONS: Our data indicate that supplementation of ascorbic acid in addition to routine postoperative care does not reduce atrial fibrillation after coronary artery bypass grafting. (C) 2012 Elsevier Inc. All rights reserved.